MUSCLE SHEAR WAVE ELASTOGRAPHY IN INCLUSION BODY MYOSITIS: FEASIBILITY, RELIABILITY AND RELATIONSHIPS WITH MUSCLE IMPAIRMENTS
MUSCLE SHEAR WAVE ELASTOGRAPHY IN INCLUSION BODY MYOSITIS: FEASIBILITY, RELIABILITY AND RELATIONSHIPS WITH MUSCLE IMPAIRMENTS
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DOI：
10.1016/j.ultrasmedbio.2018.03.026
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发表时间：
2018-07-01
影响因子：
2.9
通讯作者：
Hogrel, Jean-Yves
中科院分区：
文献类型：
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作者：
Bachasson, Damien;Dubois, Guillaume J. R.;Hogrel, Jean-Yves
退行性肌肉变化可能与肌肉机械特性的变化有关。剪切波弹性成像 (SWE) 可以直接量化肌肉剪切模量 (MSM)。本研究的目的是评估 SWE 在包涵体肌炎中观察到的严重肌肉紊乱的可行性和可靠性。为了探索 SWE 的临床相关性，研究了 MSM 值与 unci 级别肌肉损伤（无力和超声衍生的肌肉厚度和回声强度）之间的潜在关系。对 34 名患有包涵体肌炎的患者进行了 100 度、90 度、70 度和 10 度肘部屈曲时的肱二头肌 SWE，在从 70 度到 10 度肘角以 4 度/秒的速度进行 5 个被动牵拉-缩短周期之前和之后以及在 3 次最大自主收缩之后评估了 MSM，以评估肌肉预训练的潜在效果。日内和日间值的组内相关系数和测量标准误差分别为 > 0.83 和 < 1.74 kPa，以及 > 0.64 和 < 1.89 kPa。未发现被动加载-卸载和最大自主收缩的显着影响（所有 p 值 > 0.18）。 MSM 与预测的肌肉力量相关（所有 Spearman 相关系数 (rho) > 0.36；所有 p 值 < 0.05）。仅在 70 度时，肌肉回波强度和肌肉剪切模量之间存在显着相关性 (rho = 0.38，p < 0.05)。肌肉厚度和 MSM 之间没有发现相关性（所有 rho 值均 > 0.23，所有 p 值均 > 0.25）。肌肉 SWE 的日内和日间可靠性分别为令人满意和中等。 SWE 有望评估严重紊乱的肌肉的机械性能变化。需要进一步的研究来澄清这些发现并完善其临床价值。 (c) 2018 年世界超声医学与生物学联合会。版权所有。
Degenerative muscle changes may be associated with changes in muscle mechanical properties. Shear wave elastography (SWE) allows direct quantification of muscle shear modulus (MSM). The aim of this study was to evaluate the feasibility and reliability of SWE in the severely disordered muscle as observed in inclusion body myositis. To explore the clinical relevance of SWE, potential relationships between MSM values unci level muscle impairments (weakness and ultrasound-derived muscle thickness and echo intensity) were investigated. SWE was performed in the biceps brachii at 100 degrees, 90 degrees, 70 degrees and 10 degrees elbow flexion in 34 patients with inclusion body myositis, MSM was assessed before and after five passive stretch-shortening cycles at 4 degrees/s from 70 degrees to 10 degrees elbow angle and after three maximal voluntary contractions to evaluate potential effects of muscle preconditining. Intra-class correlation coefficients and standard errors of measurements were > 0.83 and < 1.74 kPa and > 0.64 and < 1.89 kPa for within- and between-day values, respectively. No significant effect of passive loading-unlading and maximal voluntary contractions was found (all p values > 0.18). MSM correlated to predicted muscle strength (all Spearman correlation coefficients (rho) > 0.36; all p values < 0.05). A significant correlation was found between muscle echo intensity and muscle shear modulus at 70 degrees only (rho = 0.38, p < 0.05). No correlation was found between muscle thickness and MSM (all rho values > 0.23 and all p values > 0.25, respectively). Within- and between-day reliability of muscle SWE was satisfactory and moderate, respectively. SWE shows promise for assessing changes in mechanical properties of the severely disordered muscle. Further investigations are required to clarify these findings and to refine their clinical value. (c) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.