Phlebotomus-transmitted toscana virus infections of the central nervous system: A seven-year experience in Tuscany
Phlebotomus-transmitted toscana virus infections of the central nervous system: A seven-year experience in Tuscany
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DOI：
10.1080/00365549850161539
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发表时间：
1998-01-01
影响因子：
--
通讯作者：
Toscano, L
中科院分区：
文献类型：
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作者：
Braito, A;Ciufolini, MG;Toscano, L
托斯卡纳病毒(TOSv)是最近发现的一种由白纹伊蚊传播的人类病原体，涉及意大利夏季自然疫源地发生的急性中枢神经系统(CNS)感染。这项前瞻性研究的目的是调查1990~1996年锡耶纳医院感染科收治的170例疑似病毒性脑膜炎-脑膜脑炎患者中该病毒的作用。用常规病毒学方法常规诊断森林脑炎病毒(TBEv)和TOSv等嗜神经病毒感染。89例被归因于TOSv，其中约10%是在托斯卡纳度假的欧洲人。所有TOSv阳性病例仅在夏季观察到，仅在锡耶纳及其省海拔不超过500米的丘陵地区的居民中观察到，多年来病例数量有所增加，年轻人中发病率较高。临床表现与观察到的其他中枢神经系统病毒感染相似。所有病例的演变都是良性的；2名受试者出现脑炎症状和体征。
Toscana virus (TOSv) is a recently discovered Phlebotomus-transmitted human pathogen involved in acute infections of the central nervous system (CNS) occurring during the summer in natural foci in Italy. The purpose of this prospective study was to investigate the role of this virus in 170 patients with meningitis-meningoencephalitis of suspected viral origin, admitted to the Departments of Infectious Diseases at the Siena Hospital from 1990 to 1996, Infections caused by tick-borne encephalitis virus (TBEv) and TOSv or other neurotropic viruses were routinely diagnosed by means of conventional virological methods. 89 cases were attributed to TOSv, about 10% of which were Europeans on vacation in Tuscany. All of the TOSv-positive cases mere observed during the summer and mere residents of hilly areas in Siena and its province at an altitude not above 500 m, An increase in the number of cases was observed over the years, with a higher incidence among younger people. The clinical picture was similar to that observed in other viral infections of the CNS. Evolution was benign in all cases; in 2 subjects symptoms and signs of encephalitis were present.