ANALYSIS OF THE GENETIC STRUCTURE OF LIFE HISTORY OF DROSOPHILA MELANOGASTER USING RECOMBINANT EXTRACTED LINES
ANALYSIS OF THE GENETIC STRUCTURE OF LIFE HISTORY OF DROSOPHILA MELANOGASTER USING RECOMBINANT EXTRACTED LINES
复制标题
利用重组提取系分析果蝇生活史的遗传结构
DOI：
--
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
A. Clark
中科院分区：
文献类型：
--
作者：
D. Hughes;A. Clark
一种被称为“拮抗多效性”的衰老进化模型做出了具体的预测，即与适应性相关的早期和晚期特征之间应该存在负遗传相关。该模型先前已通过经典的定量遗传手段进行了测试，包括同胞分析和人工选择。我们使用染色体提取的方法来进一步测试模型，该方法与传统方法相比有优点和缺点。从黑腹果蝇的4个等基因系中，利用标准平衡染色体技术构建了4组重组提取系。4个亲本系和53个重组系在受控的实验室条件下饲养，并成对分离进行日繁殖力和寿命评分。尽管这种设计对于估计遗传变异的经典成分来说不是最优的，但它提供了对环境协方差大小的独特直接测试，同时给出了部分基因组的详细遗传图。重组系在平均寿命和早期繁殖力分布上存在明显差异。早期繁殖力（羽化后前5天的产蛋量总和）与雌性寿命之间的遗传相关性仅在一个重组系列中呈显著负相关。当所有品系一起考虑时，这些性状之间的表型相关性显著为负（P < 0.02），而广义遗传相关性为-0.219 （P < 0.11）。这一结果可能被视为与拮抗多效性模型弱一致，但数据的其他方面与模型不一致。
A model for the evolution of senescence known as “antagonistic pleiotropy” makes the specific prediction that there should be a negative genetic correlation between early‐ and late‐age traits associated with fitness. This model has previously been tested by classical quantitative‐genetic means including sib‐analysis and artificial selection. We used the approach of chromosome extraction, which has both advantages and disadvantages compared to classical techniques, to test the model further. From four isogenic lines of Drosophila melanogaster, four sets of recombinant extracted lines were constructed using standard balancer‐chromosome techniques. The four parental lines and 53 recombinants were reared under controlled laboratory conditions and isolated as pairs for scoring daily fecundity and longevity. Even though the design is not optimal for estimating classical components of genetic variance, it afforded a uniquely direct test of the magnitude of environmental covariances, while giving a detailed genetic picture of part of the genome. There were clear differences among the recombinant series in the distribution of mean longevity and early fecundity. The genetic correlation between early fecundity (sum of egg production for the first five days posteclosion) and female longevity was significantly negative in only one of the recombinant series. When all lines were considered together, the phenotypic correlation between these traits was significantly negative (P < 0.02), while the broad‐sense genetic correlation was –0.219 (P < 0.11). This result may be viewed as weakly consistent with the model of antagonistic pleiotropy, but other aspects of the data are at odds with the model.
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影响因子：
3.3
作者：
Rebecca Gelman;Ada Watson;Roderick Bronson;Edmond J. Yunis
通讯作者：
Rebecca Gelman;Ada Watson;Roderick Bronson;Edmond J. Yunis
果蝇寿命延长的遗传学。
DOI：
10.1002/bies.950110505
发表时间：
1989
期刊：
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子：
--
作者：
Rose,MR
通讯作者：
Rose,MR
DOI：
10.1073/pnas.84.7.1974
发表时间：
1987
影响因子：
11.1
作者：
Mueller,LD
通讯作者：
Mueller,LD
影响果蝇生活史的因素的遗传学。
影响因子：
3.3
作者：
Hiraizumi,Y
通讯作者：
Hiraizumi,Y