Fluctuation in systolic blood pressure is a major systemic risk factor for development of primary open-angle glaucoma.
Fluctuation in systolic blood pressure is a major systemic risk factor for development of primary open-angle glaucoma.
复制标题
DOI：
10.1038/srep43734
复制
发表时间：
2017-03-06
影响因子：
4.6
通讯作者：
Park CK
中科院分区：
文献类型：
--
作者：
Lee NY;Jung Y;Han K;Park CK
我们使用韩国国民健康保险研究数据库进行了一项全国性的、基于人群的、为期11年的纵向研究，评估了原发性开角型青光眼（POAG）发生的风险。我们纳入了在2002年1月至2006年12月期间接受两次以上医疗保健检查的患者。我们将所有受试者按收缩压（SBP）、舒张压（DBP）以及收缩压和舒张压之差的变异性四分位数进行分组。在纳入的80，021例受试者中，910例在2007年1月至2013年12月期间被诊断为POAG。Kaplan-Meier生存曲线和log-rank检验数据均表明，高血压变异性患者发生POAG的频率显著高于低血压变异性患者（P < 0.001）。在包括性别、年龄、性别、家庭收入、吸烟状况、饮酒水平、运动程度、糖尿病状况、血脂异常状况、SBP和DBP的多变量考克斯回归模型中，SD SBP和CV SBP的最高和最低四分位数之间的风险比分别为1.256和1.238。我们的研究结果表明，在我们的韩国成人人群样本中，SBP变异性最高的四分位数的受试者更有可能发展为POAG。
We evaluated the risk of development of primary open-angle glaucoma (POAG) in terms of variability in BP using a nationwide, population-based, 11-year longitudinal study using the Korean National Health Insurance Research Database. We included patients who underwent health care examinations more than twice between January 2002 and December 2006. We divided all subjects by the quartiles of variability in systolic blood pressure (SBP), diastolic blood pressure (DBP), and the difference between SBP and DBP. Of the total of 80,021 included subjects, 910 were diagnosed with POAG between January 2007 and December 2013. Both the Kaplan-Meier survival curves and log-rank test data indicated that patients with higher-level BP variability developed POAG significantly more frequently than did patients with lower-level variability (P < 0.001). On multivariate Cox’s regression modeling including gender, age, sex, household income, smoking status, level of alcohol intake, extent of exercise, diabetes mellitus status, dyslipidemia status, SBP, and DBP; the hazard ratios among the highest and lowest quartiles of SD SBP and CV SBP were 1.256 and 1.238, respectively. Our findings suggest that subjects in the highest quartile of SBP variability were significantly more likely to develop POAG in our population-based sample of Korean adults.