Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
复制标题
DOI：
10.1002/term.3115
复制
发表时间：
2020-08-17
影响因子：
3.3
通讯作者：
Aftab, Saira
中科院分区：
文献类型：
--
作者：
Khan, Muhammad Umar Aslam;Raza, Mohsin Ali;Aftab, Saira
开发具有生物相容性和抗菌性能的活性生物大分子伤口敷料材料是一项具有挑战性的任务。本工作的重点是使用阿拉伯木聚糖（ARX）和瓜尔胶（GG）天然聚合物制备生物相容性和可降解的水凝胶用于伤口敷料应用。傅里叶变换红外光谱（FT-IR）证实了ARX和GG之间存在良好的相互作用，交联剂正硅酸乙酯的加入进一步增强了它们之间的相互作用。扫描电子显微镜（SEM）显微照片显示均匀的多孔形态的水凝胶。多孔形态和均匀互连的孔归因于水凝胶的增加的交联。水凝胶的弹性模量、拉伸强度和断裂应变随着交联而显著提高（从ATG-1到ATG-4）。降解性测试显示，水凝胶在7天内损失最大重量。所有的样品都表现出溶胀随pH值的变化。在pH 7时观察到最大溶胀。水凝胶样品在PBS中对铜绿假单胞菌（革兰氏阴性）和金黄色葡萄球菌（革兰氏阳性）表现出良好的抗菌活性，良好的药物释放曲线（92%药物释放）和无毒的细胞行为。细胞不仅在水凝胶上保持其圆柱形形态，而且还进行其正常活动。因此，我们认为，所开发的水凝胶可能是一种潜在的伤口敷料应用材料。
It is a challenging task to develop active biomacromolecular wound dressing materials that are biocompatible and possesses antibacterial properties against the bacterial strains that cause severe skin disease. This work is focused on the preparation of a biocompatible and degradable hydrogel for wound dressing application using arabinoxylan (ARX) and guar gum (GG) natural polymers. Fourier transform infrared spectroscopy (FT-IR) confirmed that both ARX and GG interacted well with each other, and their interactions further increased with the addition of crosslinker tetraethyl orthosilicate. Scanning electron microscope (SEM) micrographs showed uniform porous morphologies of the hydrogels. The porous morphologies and uniform interconnected pores are attributed to the increased crosslinking of the hydrogel. Elastic modulus, tensile strength, and fracture strain of the hydrogels significantly improved (from ATG-1 to ATG-4) with crosslinking. Degradability tests showed that hydrogels lost maximum weight in 7 days. All the samples showed variation in swelling with pH. Maximum swelling was observed at pH 7. The hydrogel samples showed good antibacterial activity againstPseudomonas aeruginosa(Gram-negative) andStaphylococcus aureus(Gram-positive) in PBS, good drug release profile (92% drug release), and nontoxic cellular behavior. The cells not only retained their cylindrical morphologies onto the hydrogel but were also performing their normal activities. It is, therefore, believed that as-developed hydrogel could be a potential material for wound dressing application.