Appetite and adverse effects associated with radiation therapy in patients with head and neck cancer.
Appetite and adverse effects associated with radiation therapy in patients with head and neck cancer.
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头颈癌患者与放射治疗相关的食欲和不良反应。
DOI：
10.1016/j.ejon.2009.07.004
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Y. Shimizu
中科院分区：
文献类型：
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作者：
Norimasa Ogama;Sumie Suzuki;K. Umeshita;Tamami Kobayashi;Shoko Kaneko;Sakiko Kato;Y. Shimizu
为研究放射治疗与头颈部肿瘤患者食欲不良反应的关系。方法采用SAMPLEPath分析方法，对117例接受放射治疗的头颈部肿瘤患者的下列因素进行评估：唾液日波动、止痛药的使用、口腔护理频率、受试者特征和食欲。结果20Gy射线照射后，食欲受Brinkman指数、年龄和味觉敏感性的影响(R2=0.48，p<；0.001)；在30Gy射线照射时，食欲受口腔护理频率、口腔干燥症状、年龄、对味觉的敏感性和口腔粘膜炎的影响(R2=0.52p<；0.001)，而在50Gy射线照射时，食欲受早晨低唾液分泌、口腔护理频率、口干症症状、对味道的敏感性、止痛药的使用和口腔粘膜炎的影响(R2=0.62p<；0.001)。这些发现为卫生保健专业人员了解和支持接受放射治疗的H&N癌症患者适当的饮食摄入和改善生活质量提供了重要数据。
PURPOSEThe relationship between radiation treatment and adverse effects resulting in changes in appetite was studied in patients with head and neck (H&N) cancer.METHODS AND SAMPLEPath analysis was used to evaluate the following factors in 117 patients receiving radiation therapy for H&N cancer: daily fluctuations in saliva production, analgesic use, frequency of oral care, subject characteristics, and appetite.RESULTSAt 20Gy of radiation, appetite was affected by Brinkman index value, age, and sensitivity to taste (R2=0.48, p<0.001); at 30Gy of radiation, appetite was affected by frequency of oral care, xerostomia symptoms, age, sensitivity to taste, and oral mucositis (R2=0.52, p<0.001); and at 50Gy of radiation, appetite was affected by low saliva production in the morning, frequency of oral care, xerostomia symptoms, sensitivity to taste, analgesic use, and oral mucositis (R2=0.62, p<0.001).CONCLUSIONSThe results of this study suggest that care taken to avoid a decrease in appetite due to adverse effects of radiation therapy should differ according to the dosage and schedule of radiation therapy. These findings represent important data for health care professionals to understand and support appropriate dietary intake and improved quality of life for H&N cancer patients receiving radiation therapy.