PB@Au Core-Satellite Multifunctional Nanotheranostics for Magnetic Resonance and Computed Tomography Imaging in Vivo and Synergetic Photothermal and Radiosensitive Therapy
PB@Au Core-Satellite Multifunctional Nanotheranostics for Magnetic Resonance and Computed Tomography Imaging in Vivo and Synergetic Photothermal and Radiosensitive Therapy
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PB@Au 核心卫星多功能纳米治疗学用于体内磁共振和计算机断层扫描成像以及协同光热和放射敏感治疗
DOI：
10.1021/acsami.6b13493
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发表时间：
2017-01-18
影响因子：
9.5
通讯作者：
Chang, Jin
中科院分区：
文献类型：
--
作者：
Dou, Yan;Yang, Xue;Chang, Jin
通过简单有效的方法将多种诊断和治疗策略整合到单个颗粒上仍然是纳米治疗诊断学的挑战。本文以普鲁士蓝纳米粒子（PBNPs）为基础，研制了多功能纳米治疗诊断用PB@Au核卫星纳米粒子（CSNPs）。金纳米粒子（AuNPs）是两种内在的治疗诊断纳米材料，用于磁共振（MR）-计算机断层扫描（CT）成像和协同光热和放射敏感治疗（PTT-AT）。PBNPs作为核心能够实现T-1和T-2加权MR对比度和强光热效应，而AuNPs作为卫星提供CT增强和放射增敏。如MR和CT成像所揭示的，CSNPs通过静脉注射后的被动靶向积聚实现有效的肿瘤定位。体内研究表明，CSNP导致协同PTT-RT作用，以实现几乎完全抑制肿瘤生长而没有可观察到的复发。此外，没有明显的小鼠全身毒性，证实了CSNPs的良好生物相容性。这些结果提出了新的可能性，临床nanotheranostics与多模式诊断和治疗结合设计。
To integrate multiple diagnostic and therapeutic strategies on a single particle through simple and effective methods is still challenging for nanotheranostics. Herein, we develop multifunctional nanotheranostic PB@Au core-satellite nanoparticles (CSNPs) based on Prussian blue nanoparticles (PBNPs) and. gold nanoparticles (AuNPs), which are two kinds of intrinsic theranostic nanomaterials, for magnetic resonance (MR)-computed tomography (CT) imaging and synergistic photothermal and radiosensitive therapy (PTT-AT). PBNPs as cores enable T-1- and T-2-weighted MR contrast and strong photothermal effect, while AuNPs as satellites offer CT enhancement and radiosensitization. As revealed by both MR and CT imaging, CSNPs realized efficient tumor localization by passively targeted accumulation after intravenous injection. In vivo studies showed that CSNPs resulted in synergistic PTT-RT action to achieve almost entirely suppression of tumor growth without observable recurrence. Moreover, no obvious systemic toxicity of mice confirmed good biocompatibility of CSNPs. These results raise new possibilities for clinical nanotheranostics with multimodal diagnostic and therapeutic coalescent design.