Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam
Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam
复制标题
DOI：
10.1016/j.vaccine.2006.03.008
复制
发表时间：
2006-05-15
期刊：
影响因子：
5.5
通讯作者：
Clemens, John D.
中科院分区：
文献类型：
--
作者：
Thiem, Vu Dinh;Deen, Jacqueline L.;Clemens, John D.
我们评估了越南生产的灭活全细胞口服霍乱疫苗提供的长期保护。1998年，在越南顺化一半的乡镇对儿童和成人进行了大规模的灭活全细胞口服霍乱疫苗免疫接种; 2000年对其余乡镇进行了免疫接种。在顺化没有发现霍乱，直到2003年埃尔托尔霍乱爆发，才得以进行病例对照研究。接种后3-5年的总体疫苗有效性为50%（9-63%）。这种低成本、易于接种的疫苗应被视为控制霍乱的一种工具。(c)2006爱思唯尔有限公司保留所有权利。
We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera. (c) 2006 Elsevier Ltd. All rights reserved.