Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection
Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection
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DOI：
10.1016/j.antiviral.2011.08.003
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发表时间：
2011-11-01
影响因子：
7.6
通讯作者：
Block, Timothy M.
中科院分区：
文献类型：
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作者：
Chang, Jinhong;Schul, Wouter;Block, Timothy M.
登革病毒感染会导致人类疾病，从急性发热性疾病登革热到危及生命的登革出血热/登革休克综合征。我们先前报道了宿主细胞α-葡萄糖苷酶I和II抑制剂，亚氨基糖CM-10-18，有效地抑制登革热病毒在培养细胞中的复制，并显着减少登革热病毒感染的AG 129小鼠的病毒血症。在这份报告中，我们表明，CM-10-18也显着保护小鼠免于死亡和/或疾病的进展，在两个小鼠模型的致命登革病毒感染。因此，我们的研究结果为CM-10-18或其衍生物作为治疗严重登革病毒感染的抗病毒药物的开发提供了强有力的支持。(C)2011 Elsevier B. V.保留所有权利。
Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular alpha-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections. (C) 2011 Elsevier B.V. All rights reserved.