Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia
Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia
复制标题
DOI：
10.1016/j.ajog.2005.12.049
复制
发表时间：
2006-07-01
影响因子：
9.8
通讯作者：
Wang, Wei
中科院分区：
文献类型：
--
作者：
Robinson, Christopher J.;Johnson, Donna D.;Wang, Wei
目的：本研究的目的是确定重度子痫前期患者的母体血清胎盘生长因子（PIGF）和可溶性 Fins 样酪氨酸激酶 1 受体（s-Flt1）浓度是否比轻度子痫前期更异常。研究设计：收集了 32 名对照患者和 80 名轻度或重度子痫前期患者的血清样本。通过酶联免疫吸附测定 (ELISA) 对 PIGF 和 s-Flt1 浓度进行定量。除非另有说明，结果表示为中位数 (Q1-Q3)。标准化后，使用单向协方差分析 (ANCOVA) 比较血清标志物。结果：先兆子痫患者的 PIGF 水平降低（75.1 +/- 14 vs 391 +/- 54 pg/mL，P < .0001），s-Flt1 浓度升高（1081 +/- 108 vs 100.1 +/- 26.9 pg/mL，P < 0.0001）。 .0001）与各自的对照相比（平均值+/-SEM）。与重度先兆子痫患者相比，轻度先兆子痫患者的 PIGF 浓度分别较低（67 pg/mL [39-158] vs 24 pg/mL [4-57]，P < .02）。轻度和重度子痫前期之间 s-Flt1 没有差异（674 pg/mL [211-1297] vs 1015 pg/mL [731-1948]，P = .08）。结论：与对照组相比，子痫前期患者 PIGF 和 s-Flt1 血清水平异常，但与轻度子痫前期相比，重度子痫前期仅 PIGF 异常程度更高。 (c) 2006 Mosby, Inc. 保留所有权利。
Objective: The purpose of this study was to determine if maternal serum concentrations of placenta growth factor (PIGF) and soluble Fins-like tyrosine kinase 1 receptor (s-Flt1) are more abnormal in patients with severe preeclampsia compared with mild preeclampsia.Study design: Serum samples were collected from 32 control patients and 80 patients with mild or severe preeclampsia. PIGF and s-Flt1 concentrations were quantitated by enzyme-linked immunosorbent assay (ELISA). Results are expressed as median (Q1-Q3) unless stated otherwise. After normalization, serum markers were compared using one-way analysis of covariance (ANCOVA).Results: Patients with preeclampsia had decreased levels of PIGF (75.1 +/- 14 vs 391 +/- 54 pg/mL, P < .0001) and elevated s-Flt1 concentration (1081 +/- 108 vs 100.1 +/- 26.9 pg/mL, P < .0001) compared with the respective controls (mean +/- SEM). PIGF concentration was lower in patients with mild preeclampsia compared with severe, respectively (67 pg/mL [39-158] vs 24 pg/mL [4-57], P < .02). s-Flt1 was not different between mild and severe preeclampsia (674 pg/mL [211-1297] vs 1015 pg/mL [731-1948], P = .08).Conclusion: PIGF and s-Flt1 serum levels are abnormal in patients with preeclampsia compared with controls, but only PIGF is more abnormal in severe preeclampsia compared with mild preeclampsia. (c) 2006 Mosby, Inc. All rights reserved.