Immediate-early gene activation by the MAPK pathways: what do and don't we know?
Immediate-early gene activation by the MAPK pathways: what do and don't we know?
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DOI：
10.1042/bst20110636
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Sharrocks, Andrew D.
中科院分区：
文献类型：
--
作者：
O'Donnell, Amanda;Odrowaz, Zaneta;Sharrocks, Andrew D.
IE（立即早期）基因激活机制的研究为如何响应细胞外信号传导控制转录提供了许多范例。许多发现源自对 IE 基因之一 FOS 的研究，以及外推其他 IE 基因调控机制的模型。然而，虽然激活的总体原理看起来相似，但最近的证据表明，潜在的机制细节可能因细胞类型、细胞刺激和所研究的 IE 基因而异。在本文中，我们回顾了对 IE 基因转录理解的最新进展，主要关注 FOS 及其通过 ERK（细胞外信号调节激酶）MAPK（丝裂原激活蛋白激酶）信号通路的激活。我们强调了重要的基本监管原则，但也说明了我们当前知识的差距以及基于不同研究的推断而做出假设的潜在危险。
The study of IE (immediate-early) gene activation mechanisms has provided numerous paradigms for how transcription is controlled in response to extracellular signalling. Many of the findings have been derived from investigating one of the IE genes, FOS, and the models extrapolated to regulatory mechanisms for other IE genes. However, whereas the overall principles of activation appear similar, recent evidence suggests that the underlying mechanistic details may differ depending on cell type, cellular stimulus and IE gene under investigation. In the present paper, we review recent advances in our understanding of IE gene transcription, chiefly focusing on FOS and its activation by ERK (extracellular-signal-regulated kinase) MAPK (mitogen-activated protein kinase) pathway signalling. We highlight important fundamental regulatory principles, but also illustrate the gaps in our current knowledge and the potential danger in making assumptions based on extrapolation from disparate studies.