Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection.
Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection.
复制标题
实验性麻疹病毒感染中 T 淋巴细胞反应的选择性体内抑制。
DOI：
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发表时间：
2000
影响因子：
11.1
通讯作者：
V. ter meulen
中科院分区：
文献类型：
--
作者：
S. Niewiesk;M. Götzelmann;V. ter meulen
During and after measles virus (MV) infection humans are highly susceptible to opportunistic infections because of a marked immunosuppressive effect of the virus. The mechanisms by which the virus induces this phenomenon is not well understood. In particular, detailed information is missing on the targets of suppression in relation to antigen-specific T and B cell responses. Because such studies require animal experiments, we used the cotton rat model, in which the MV causes a respiratory tract infection. Primary as well as secondary T cell responses were impaired in vivo and ex vivo by MV infection. The proliferation of T cells was greatly reduced, but their effector functions, such as cytolysis or cytokine secretion, were not. In contrast, primary and secondary B cell responses in vivo as measured by the frequency of antigen-specific plasma cells in an enzyme-linked immunospot (ELISPOT) assay were not altered by MV infection. Only the secretion of immunoglobulins was reduced slightly in animals primarily infected with MV after 2 weeks. These data demonstrate that MV-induced immunosuppression acts primarily on the T cell responses in vivo.
麻疹病毒抑制丝裂原诱导的 T 细胞增殖，但不会直接干扰细胞内 T 细胞的激活过程。
影响因子：
3.7
作者：
Yanagi,Y;Cubitt,BA;Oldstone,MB
通讯作者：
Oldstone,MB