Executive Dysfunction in Remitted Late-Life Depression: Juntendo University Mood Disorder Projects (JUMP)
Executive Dysfunction in Remitted Late-Life Depression: Juntendo University Mood Disorder Projects (JUMP)
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DOI：
10.1176/appi.neuropsych.22.1.70
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发表时间：
2010-12-01
影响因子：
2.9
通讯作者：
Arai, Heii
中科院分区：
文献类型：
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作者：
Baba, Kanako;Baba, Hajime;Arai, Heii
作者的目的是研究成人和老年重度抑郁症患者是否表现出不同的执行功能障碍模式。采用《执行障碍综合征行为评估》对20例心境性重度抑郁症患者和29例健康对照者的执行功能进行了评估。与成年患者和健康对照者相比，老年健郁患者在修正六行亚测试中表现出更大的损伤。由于该亚测试中涉及最多的区域是内侧前额叶、前扣带和背外侧前额叶区域，因此作者得出结论，即使在晚年抑郁症缓解期，这些额叶神经网络的功能障碍仍未得到解决。（神经精神病学与临床神经科学杂志2010；22:70-74）
The authors aimed to investigate whether remitted adult and elderly major depressive disorder patients show different patterns of executive dysfunction. Executive functions of 20 euthymic major depressive disorder patients and 29 healthy comparison subjects were evaluated using the Behavioral Assessment of the Dysexecutive Syndrome. Relative to adult patients and healthy comparison subjects, euthymic elderly patients were more impaired in the subtest of Modified Six Elements. Since the regions most implicated in this subtest are the medial prefrontal, the anterior cingulate, and the dorsolateral prefrontal areas, the authors conclude that dysfunctions of such frontal neural networks remain unresolved even in the remission phase of late-life depression. (The Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22:70-74)