Temporal trends in antidepressant prescribing to children in UK primary care, 2000-2015.
Temporal trends in antidepressant prescribing to children in UK primary care, 2000-2015.
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DOI：
10.1016/j.jad.2016.12.047
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发表时间：
2017-03-01
影响因子：
6.6
通讯作者：
Ashcroft DM
中科院分区：
文献类型：
--
作者：
Sarginson J;Webb RT;Stocks SJ;Esmail A;Garg S;Ashcroft DM
2005年至2012年期间，尽管有监管安全警告，但美国和欧洲部分地区儿童和青少年抗抑郁药处方的流行率稳步上升。人们对第一次服用抗抑郁药的人的特征知之甚少。使用2000年至2015年期间英国临床实践研究数据链（CPRD）的数据，对3-17岁奥尔兹的抗抑郁药处方进行了纵向研究。研究了首次开抗抑郁药处方的发生率变化和处方者的特征。2006年至2015年间，首次处方的发生率几乎翻了一番，从每1000人年1.60（95%CI：1.51，1.69）上升至3.12（3.00，3.25）。2015年，在1721名有意外处方的患者中，只有21%与抑郁症诊断有关，另外22%的处方与替代适应症有关。与抑郁症诊断相关的处方发生率在2012年至2015年期间增加，调整后的发生率比率为1.46（1.26，1.70）。用于抑郁症和其他适应症的抗抑郁药处方在15至17岁的女性中增长最快。诊断与CPRD中的处方没有直接联系，因此必须通过时间接近性来推断联系。2006年至2015年期间，儿童的抗抑郁药处方增加。这至少部分是由于抗抑郁药的替代用途增加，包括治疗焦虑，慢性疼痛和偏头痛。
The prevalence of antidepressant prescribing in children and adolescents increased steadily in the United States and parts of Europe between 2005 and 2012 despite regulatory safety warnings. Little is known about the characteristics of those being prescribed antidepressants for the first time. A longitudinal study of antidepressant prescribing in 3–17 year olds was carried out using data from the UK Clinical Practice Research Datalink (CPRD) between 2000 and 2015. Changes in the incidence of first ever antidepressant prescriptions and the characteristics of those being prescribed them was examined. Incidence of first ever prescriptions nearly doubled between 2006 and 2015 rising from 1.60 (95%CI: 1.51, 1.69) to 3.12 (3.00, 3.25) per 1000 person years. Only 21% of the 1721 patients with incident prescriptions in 2015 could be linked to a depression diagnosis, with an additional 22% of prescriptions linked to alternative indications. The incidence of prescriptions linked to a depression diagnosis increased between 2012 and 2015, with an adjusted incidence rate ratio of 1.46 (1.26, 1.70). Antidepressant prescribing for depression and other indications has been increasing most rapidly in 15 to 17 year old females. Diagnoses are not directly linked to prescriptions in CPRD, so linkage must be inferred by temporal proximity. Antidepressant prescribing in children increased between 2006 and 2015. This is, at least in part, due to a rise in alternative uses of antidepressants, including the treatment of anxiety, chronic pain and migraines.