Abnormal nuclear shape in solid tumors reflects mitotic instability
Abnormal nuclear shape in solid tumors reflects mitotic instability
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DOI：
10.1016/s0002-9440(10)63958-2
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发表时间：
2001-01-01
影响因子：
6
通讯作者：
Mandahl, N
中科院分区：
文献类型：
--
作者：
Gisselsson, D;Björk, J;Mandahl, N
核形态异常常见于恶性肿瘤组织，但其机制尚不清楚，本研究在短期肿瘤细胞培养中探讨了核形态异常与染色体不稳定性之间的关系。在5例恶性软组织肿瘤中，用荧光原位杂交技术鉴定了分裂不稳定环和双着丝粒染色体，并定位于间期细胞核。绝大多数(71%至86%)的核泡、染色质串和微核含有来自不稳定染色体的物质，而极少数(
Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood, In this study, the relation between abnormal nuclear shape and chromosomal instability was explored in short-term tumor cell cultures. Mitotically unstable ring and dicentric chromosomes were identified by fluorescence in situ hybridization at metaphase and subsequently localized in interphase nuclei from five malignant soft tissue tumors. The vast majority (71 to 86%) of nuclear blebs, chromatin strings, and micronuclei contained material from the unstable chromosomes, whereas few (