A rat model study of atrophy of denervated musculature of the hand being faster than that of denervated muscles of the arm
A rat model study of atrophy of denervated musculature of the hand being faster than that of denervated muscles of the arm
复制标题
大鼠模型研究，手部失神经肌肉组织的萎缩速度快于手臂失神经肌肉组织的萎缩速度
DOI：
10.1007/s10974-012-9328-3
复制
发表时间：
2013-02-01
影响因子：
2.7
通讯作者：
Gu, Yu-dong
中科院分区：
文献类型：
--
作者：
Wu, Ji-xin;Chen, Liang;Gu, Yu-dong
神经损伤后失神经肌肉萎缩是否不可逆，尚无生物学标志。临床上产科臂丛神经麻痹（obstricbranchplexus paralysis，OBPP）中，失神经支配的手内肌萎缩比失神经支配的臂肌萎缩更快至不可逆。将64只C5 C6切断、C7 C8 T1撕脱的幼鼠分为重建组和对照组，每组10只。尺神经组分为R1、R5、R10、R15亚组，分别于伤后1、5、10、15周行尺神经和肌皮神经重建，12周后评价疗效。后者分为C1、C5、C10、C15亚组，分别于伤后1、5、10、15周对两条神经的失神经肌肉进行评估。前爪固有肌肌纤维平均横截面积的结果表明，R5、R10、R15亚组均不上级C5、C10、C15亚组，而R1亚组优于C5;肱二头肌肌纤维平均横截面积的结果表明，R1、R5、R10亚组均优于C1、C5、C10亚组，而R15亚组优于C1、C5、C10亚组。在重建亚组中，每条神经中的再生神经纤维不少于对照侧的53%，而运动终板的数量在不可逆肌肉萎缩的亚组中统计学上较少。结论：OBPP大鼠模型适合于模拟失神经支配的手内肌萎缩快于失神经支配的上臂肌的临床表现。
There are no biological marks to indicate if denervated muscle atrophy after nerve injury is irreversible. Clinically in obstetric brachial plexus palsy (OBPP), atrophy of denervated intrinsic musculature of the hand is much faster to irreversible than that of denervated muscles of the arm. 64 pup rats whose C5C6 had been divided and C7C8T1 avulsed, were divided equally into the reconstruction and control groups. The former had subgroups R1, R5, R10, R15 where the ulnar and musculocutaneous nerves were reconstructed one, five, ten and 15 weeks respectively after injury and efficacy was evaluated 12 weeks later. The latter had C1, C5, C10, C15 subgroups where denervated muscles of the two nerves were assessed one, five, ten and 15 weeks after injury. Results of average cross-sectional area of the muscle fiber for intrinsic musculature of the forepaw showed that the R5, R10, R15 subgroups were not statistically superior to the C5, C10, C15 ones, respectively, though R1 was; those for biceps indicated, however, that the R1, R5, R10 subgroups were better than the C1, C5, C10 ones, respectively, though R15 was not. In the reconstruction subgroups regenerative nerve fibers in each nerve were no less than 53 percent of those on the control side, while number of motor end plates was statistically less in subgroups with irreversible muscle atrophy. We conclude that rat model of OBPP is suitable for simulating clinical appearance of atrophy of denervated intrinsic musculature of the hand being faster than that of denervated muscles of the arm.