INFANT BREAST-FEEDING AND THE RISK OF CHILDHOOD LYMPHOMA AND LEUKEMIA
INFANT BREAST-FEEDING AND THE RISK OF CHILDHOOD LYMPHOMA AND LEUKEMIA
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DOI：
10.1093/ije/24.1.27
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发表时间：
1995-02-01
影响因子：
7.7
通讯作者：
JIN, F
中科院分区：
文献类型：
--
作者：
SHU, XO;CLEMENS, J;JIN, F
背景。母乳喂养对儿童淋巴瘤有保护作用，但支持的证据有限。本文分析了上海市儿童癌症人群病例对照研究的数据，包括82例淋巴瘤病例和159例急性白血病病例及其年龄和性别匹配的社区对照。在对潜在的混杂变量进行校正后，在婴儿时期接受母乳喂养的儿童中，与未接受母乳喂养的儿童相比，发生淋巴瘤的风险略有降低（虽然不显著）（优势比[OR] = 0.69; 95% Cl: 0.3-1.7）。对于母乳喂养时间较长的儿童，减少的幅度更大，似乎主要与何杰金氏病和6岁前确诊的病例有关。不出所料，没有。降低与母乳喂养相关的急性白血病的风险。虽然这些数据既没有有力支持也没有反驳研究假设，但这些数据表明，如果母乳喂养确实能降低淋巴瘤的风险，其对中国儿童的保护作用可能是适度的，并且集中在由母乳喂养时间长短、诊断年龄和癌症的组织学亚型定义的某些亚组中。
Background. A protective effect of breastfeeding on childhood lymphoma has been indicated but supportive evidence is limited.Method. Data from a population-based case-control study of childhood cancer in Shanghai, including 82 lymphoma cases and 159 acute leukaemia cases and their age- and sex-matched community controls, were analysed.Results. After adjustment for potentially confounding variables, a slight, although non-significant, reduction in risk of lymphoma was observed among children who were breastfed as infants Versus those who were not (odds ratio [OR] = 0.69; 95% Cl : 0.3-1.7). The reduction was somewhat greater for children who had been breastfed longer and appeared to pertain primarily to Hodgkin's disease and to cases diagnosed before the age of 6 years. As expected, there was no. reduction in risk of acute leukaemia associated with breastfeeding.Conclusions. Although providing neither strong support for nor refuting the study hypothesis, these data suggest that if breastfeeding does reduce the risk of lymphoma, its protective effect among Chinese children is likely modest in magnitude and concentrated in certain subgroups defined by length of breastfeeding, age at diagnosis and histological subtype of cancer.