Clinical implication of estrogen-related receptor (ERR) expression in uterine endometrial cancers
Clinical implication of estrogen-related receptor (ERR) expression in uterine endometrial cancers
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DOI：
10.1016/j.jsbmb.2009.04.012
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发表时间：
2009-08-01
影响因子：
4.1
通讯作者：
Sato, Eriko
中科院分区：
文献类型：
--
作者：
Fujimoto, Jiro;Sato, Eriko
雌激素受体（ER）α和ER β mRNA水平随着临床分期、肌层浸润和去分化而降低。另一方面，无论去分化与否，ERR α mRNA水平和组织学评分均随临床分期和肌层浸润而升高。ERR α可以在没有任何配体的情况下与类固醇受体辅激活因子家族结合，并驱动靶基因的转录活性。雌激素依赖缓解过程中，雌激素受体α/雌激素受体表达的竞争性相互作用可能与共同辅因子的使用有关。ERR α表达上调可能与子宫内膜癌的生长和进展有关。据推测，ERR α是子宫内膜癌预后因素的候选者，尽管ERR与子宫内膜癌的生长没有直接关系。(C)2009爱思唯尔有限公司保留所有权利。
Estrogen receptor (ER)alpha and ER beta mRNAs levels decreased with clinical stage, myometrial invasion and dedifferentiation. On the other hand, ERR alpha mRNA levels and histoscores increased with clinical stage and myometrial invasion, regardless of dedifferentiation. ERR alpha can bind to the steroid receptor coactivator family without any ligands, and drive transcription activity of the target genes. The competitive interaction of ERR alpha/ER expression associated with the use of common cofactors during loosing estrogen dependency might cause their expression manner. The up-regulation of ERR alpha might be related to tumor growth and advancement in uterine endometrial cancers. It is speculated that ERR alpha is a candidate for prognostic factors in uterine endometrial cancer, although ERRs are not directly related to growth of uterine endometrial cancer. (C) 2009 Elsevier Ltd. All rights reserved.