Drosophila Myc: A master regulator of cellular performance.
Drosophila Myc: A master regulator of cellular performance.
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DOI：
10.1016/j.bbagrm.2014.06.021
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Bellosta P
中科院分区：
文献类型：
--
作者：
Grifoni D;Bellosta P
The identification of the Drosophila homolog of the human MYC oncogene has fostered a series of studies aimed to address its functions in development and cancer biology. Due to its essential roles in many fundamental biological processes it is hard to imagine a molecular mechanism in which MYC function is not required. For this reason, the easily manipulated Drosophila system has greatly helped in the dissection of the genetic and molecular pathways that regulate and are regulated by MYC function. In this review, we focus on studies of MYC in the fruitfly with particular emphasis on metabolism and cell competition, highlighting the contributions of this model system in the last decade to our understanding of MYC’s complex biological nature.
