A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
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一项随机比较研究，以确定奥美拉唑对伊曲康唑口服溶液血清峰浓度的影响。
DOI：
10.1093/jac/dkg089
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Perfect,JohnR
中科院分区：
文献类型：
--
作者：
Johnson,MelissaD;Hamilton,CarolD;Drew,RichardH;Sanders,LindaL;Pennick,GennethelJ;Perfect,JohnR
为确定奥美拉唑对伊曲康唑口服液血药浓度(Cmax)的影响，我们进行了一项随机、开放、前瞻性、交叉研究。15名健康、未怀孕的成年人，每隔至少7天，分两次单次口服奥美拉唑400 mg，奥美拉唑每晚40 mg，连续7天，然后分别给药1次或2次，测定两次给药后伊曲康唑及其活性代谢物羟基伊曲康唑的Cmax、Tmax和AUC0-8，并进行比较。给药时，奥美拉唑对伊曲康唑或羟基伊曲康唑的Cmax、Tmax或AUC0-8均无显著影响。
To determine the effect of omeprazole on peak serum concentrations (Cmax) of itraconazole oral solution (IOS), we carried out a randomized, open-label, prospective, crossover study. Fifteen healthy, non-pregnant adults received a single dose of IOS 400 mg on two occasions, at least 7 days apart, with omeprazole 40 mg nightly for 7 days before either IOS dose 1 or 2.Cmax, time toCmax(Tmax) and AUC0–8were determined for itraconazole and its active metabolite, hydroxyitraconazole, for each dose and compared. Omeprazole did not significantly affect theCmax,Tmaxor AUC0–8of itraconazole or hydroxyitraconazole when administered as IOS.