UPDATE ON SOME EPIDEMIOLOGIC FEATURES OF INTERMITTENT CLAUDICATION - THE FRAMINGHAM-STUDY
UPDATE ON SOME EPIDEMIOLOGIC FEATURES OF INTERMITTENT CLAUDICATION - THE FRAMINGHAM-STUDY
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DOI：
10.1111/j.1532-5415.1985.tb02853.x
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发表时间：
1985-01-01
影响因子：
6.3
通讯作者：
MCGEE, DL
中科院分区：
文献类型：
--
作者：
KANNEL, WB;MCGEE, DL
在对5209名受试者进行的26年监测中，176名男性和119名女性发生了闭塞性外周动脉疾病，表现为间歇性跛行（IC）。发病率随着年龄的增长而急剧增加，直到75岁，在所有年龄段，男性发病率约为男性的2倍。IC的发病率与心绞痛的发病率相当，比心绞痛晚10年。吸烟、糖耐量减低和高血压是强有力的易感因素。葡萄糖耐量受损的风险在女性中比男性更大，糖尿比其他葡萄糖耐量受损指标的风险更大。吸烟对男性和女性的影响大致相同，大约是风险的两倍，并且这种影响在老年人中也是明显的。高血压使男性和女性的风险分别增加2.5至4倍。低肺活量与实质性过度风险相关。左心室肥大的ECG证据预测了两种性别的IC。血清胆固醇、相对体重和红细胞压积是弱危险因素。由主要心血管危险因素组成的风险特征预测IC比预测冠心病更好。男性和女性的死亡率分别增加了2至4倍，主要是因为并存的心血管疾病。
During 26 yr of surveillance of the Framingham Study Cohort of 5209 subjects, 176 men and 119 women developed occlusive peripheral arterial disease manifested as intermittent claudication (IC). The incidence increased sharply with age until the age of 75, with about a 2-fold male predominance at all ages. An incidence of IC comparable to that of angina pectoris was obtained 10 yr later in the life than for angina pectoris. Cigarette smoking, impaired glucose tolerance and hypertension were powerful predisposing factors. Impaired glucose tolerance was a greater risk in women than in men, and glycosuria carried a greater risk than other indicators of impaired glucose tolerance. Cigarette smoking had about the same impact in men and women, approximately doubling the risk, and the impact was discernible into advanced age. Hypertension increased risk 2.5- to 4-fold, respectively, in men and women. A low vital capacity was associated with a substantial excess risk. ECG evidence of left ventricular hypertrophy predicted IC in both sexes. Serum cholesterol, relative weight and hematocrit were weak risk factors. A risk profile made up of the major cardiovascular risk factors was better for predicting IC than for predicting coronary heart disease. Mortality was increased 2- to 4-fold in men and women, respectively, mainly because of coexistent cardiovascular disease.