EEG correlation of the discharge properties of identified neurons in the basal forebrain
EEG correlation of the discharge properties of identified neurons in the basal forebrain
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DOI：
10.1152/jn.2000.84.3.1627
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发表时间：
2000-09-01
影响因子：
2.5
通讯作者：
Zaborszky, L
中科院分区：
文献类型：
--
作者：
Duque, A;Balatoni, B;Zaborszky, L
基底前脑（BF）是一个位于大脑半球腹侧的异质结构。它含有胆碱能以及不同类型的非胆碱能皮质神经元和中间神经元，包括gaba能细胞和肽能细胞。BF构成通往皮层的丘脑外通路，其活性与皮层神经递质乙酰胆碱释放的增加有关，同时伴有脑电图（EEG）低电压快速活动（LVFA）。然而，由于缺乏对记录神经元的化学鉴定，不同BF细胞类型的具体作用在很大程度上仍然未知。本研究显示，在皮层LVFA期间，免疫细胞化学鉴定的含有胆碱能和小蛋白的神经元的放电率增加。相反，神经肽Y神经元放电增加伴随着皮层慢波。此外，我们的研究结果表明，BF神经元与不同的脑电图模式具有明显的时间关系，并且表明BF内部以及BF与皮层回路之间的相互作用比之前提出的更为动态。
The basal forebrain (BF) is a heterogeneous structure located in the ventral aspect of the cerebral hemispheres. It contains cholinergic as well as different types of noncholinergic corticopetal neurons and interneurons, including GABAergic and peptidergic cells. The BF constitutes an extrathalamic route to the cortex, and its activity is associated with an increase in cortical release of the neurotransmitter acetylcholine, concomitant with electroencephalographic (EEG) low-voltage fast activity (LVFA). However, the specific role of the different BF cell types has largely remained unknown due to the lack of chemical identification of the recorded neurons. Here we show that the firing rate of immunocytochemically identified cholinergic and parvalbumin-containing neurons increase during cortical LVFA. In contrast, increased neuropeptide Y neuron firing is accompanied by cortical slow waves. Our results, furthermore, indicate that BF neurons posses a distinct temporal relationship to different EEG patterns and suggest a more dynamic interplay within BF as well as between BF and cortical circuitries than previously proposed.