A dynamic, embodied paradigm to investigate the role of serotonin in decision-making.
A dynamic, embodied paradigm to investigate the role of serotonin in decision-making.
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DOI：
10.3389/fnint.2013.00078
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发表时间：
2013-11-21
影响因子：
3.5
通讯作者：
Krichmar JL
中科院分区：
文献类型：
--
作者：
Asher DE;Craig AB;Zaldivar A;Brewer AA;Krichmar JL
5-羟色胺（5-HT）是一种神经调质，已被归因于成本评估和伤害规避。在这篇综述中，我们看看5-HT在决策时所起的作用，当受试者面临潜在的有害或昂贵的结果。我们审查的方法来检查决策中的能量系统。我们介绍了我们小组的范式用于调查如何5-HT影响决策。特别是，我们的范例结合了计算神经科学，社会经济博弈论，人机交互和贝叶斯统计的技术。我们将强调我们以前的研究利用这种模式，这有助于扩大我们的理解5-HT的决策有关的成本评估的影响的关键发现。最后，我们提出了一个循环的多学科的方法，可以帮助解决探索5-HT和决策的复杂性，通过迭代更新我们的假设和模型，通过详尽的实验的cathonergic系统。
Serotonin (5-HT) is a neuromodulator that has been attributed to cost assessment and harm aversion. In this review, we look at the role 5-HT plays in making decisions when subjects are faced with potential harmful or costly outcomes. We review approaches for examining the serotonergic system in decision-making. We introduce our group’s paradigm used to investigate how 5-HT affects decision-making. In particular, our paradigm combines techniques from computational neuroscience, socioeconomic game theory, human–robot interaction, and Bayesian statistics. We will highlight key findings from our previous studies utilizing this paradigm, which helped expand our understanding of 5-HT’s effect on decision-making in relation to cost assessment. Lastly, we propose a cyclic multidisciplinary approach that may aid in addressing the complexity of exploring 5-HT and decision-making by iteratively updating our assumptions and models of the serotonergic system through exhaustive experimentation.