Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis.
Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis.
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DOI：
10.1155/2016/1630365
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发表时间：
2016
影响因子：
--
通讯作者：
Cha SK
中科院分区：
文献类型：
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作者：
Kim JS;Han BG;Choi SO;Cha SK
局灶节段性肾小球硬化（FSGS）是导致终末期肾病（ESRD）的蛋白尿和肾病综合征的常见原因。有两种类型的FSGS，原发性（特发性）和继发性形式。继发性FSGS与原发性FSGS相比，临床表现不太严重。然而，继发性FSGS具有重要的临床意义，因为多种肾脏疾病通过继发性FSGS的形式进展为ESRD。FSGS的定义特征是蛋白尿。FSGS的关键事件是足细胞损伤，足细胞损伤是多种因素共同作用的结果。关于这些因素如何作用于足细胞导致继发性FSGS的未回答的问题是各种各样的和不明确的。在这篇综述中，我们提供了简短的概述和新的见解FSGS，足细胞损伤，以及它们的潜在联系，为疾病的治疗提供线索。
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting clues to answer for treatment of the disease.