Exercise and Sestrin Mediate Speed and Lysosomal Activity in Drosophila by Partially Overlapping Mechanisms.
Exercise and Sestrin Mediate Speed and Lysosomal Activity in Drosophila by Partially Overlapping Mechanisms.
复制标题
运动和sestrin通过部分重叠的机制介导果蝇中的速度和溶酶体活性。
DOI：
10.3390/cells10092479
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发表时间：
2021-09-19
期刊：
影响因子：
6
通讯作者：
Wessells R
中科院分区：
文献类型：
--
作者：
Sujkowski A;Wessells R
Chronic exercise is widely recognized as an important contributor to healthspan in humans and in diverse animal models. Recently, we have demonstrated that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits in flies and mice. Knockout of Sestrins prevents exercise adaptations to endurance and flight in Drosophila, and similarly prevents benefits to endurance and metabolism in exercising mice. In contrast, overexpression of dSestrin in muscle mimics several of the molecular and physiological adaptations characteristic of endurance exercise. Here, we extend those observations to examine the impact of dSestrin on preserving speed and increasing lysosomal activity. We find that dSestrin is a critical factor driving exercise adaptations to climbing speed, but is not absolutely required for exercise to increase lysosomal activity in Drosophila. The role of Sestrin in increasing speed during chronic exercise requires both the TORC2/AKT axis and the PGC1α homolog spargel, while dSestrin requires interactions with TORC1 to cell-autonomously increase lysosomal activity. These results highlight the conserved role of Sestrins as key factors that drive diverse physiological adaptations conferred by chronic exercise.
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影响因子：
4.5
作者：
Bai H;Kang P;Hernandez AM;Tatar M
通讯作者：
Tatar M
DOI：
10.1073/pnas.1909210116
发表时间：
2019-11-19
影响因子：
11.1
作者：
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影响因子：
16.6
作者：
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通讯作者：
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影响因子：
11.1
作者：
Budanou, Andrei V.;Lee, Jun Hee;Karin, Michael
通讯作者：
Karin, Michael