Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
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DOI：
10.1210/jc.2006-1864
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发表时间：
2007-02-01
影响因子：
5.8
通讯作者：
Raff, Hershel
中科院分区：
文献类型：
--
作者：
Rosner, William;Auchus, Richard J.;Raff, Hershel
目的：本研究的目的是评价总睾酮和游离睾酮临床检测的现状。参与者：5名参与者由内分泌学会理事会指定，负责利用已发表的数据和专家意见来实现这一目标。证据：数据来自在线数据库(主要是PubMed、Ovid MEDLINE、Google Scholar)、美国病理医师学会以及参与者的临床和实验室经验。内分泌学会理事会审阅了一份较晚的草案，并提出了具体建议。结论：实验室能力验证应基于准确和精确地测量含有已知浓度的睾酮的样本的能力，而不仅仅是与使用相同方法的其他人的一致。当这种标准化到位时，应该为性别和儿童建立总睾酮和游离睾酮的标准值，并考虑到影响血清睾酮浓度的许多变量。
Objective: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone.Participants: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion.Evidence: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants.Consensus Process: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations.Conclusions: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.