SIMILARITIES BETWEEN COLD-INDUCED AND DIET-INDUCED THERMOGENESIS IN THE RAT
SIMILARITIES BETWEEN COLD-INDUCED AND DIET-INDUCED THERMOGENESIS IN THE RAT
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DOI：
10.1139/y80-130
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发表时间：
1980-01-01
影响因子：
2.1
通讯作者：
STOCK, MJ
中科院分区：
文献类型：
--
作者：
ROTHWELL, NJ;STOCK, MJ
将大鼠维持在24 ℃。C（WA;暖适应）或4. C（CA;冷适应），并饲喂颗粒饲料（WAS，CAS）或各种可口的自助餐饮食（WAC，CAC）。静息O2消耗量（.ovrhdot.VO2，29度与WAS对照组相比，WAC、CAS和CAC大鼠的C）分别显著升高15%、14%和24%。这些差异完全消除普萘洛尔注射在所有但CAC大鼠，其中VO 2保持轻微升高。实验组显示出对去甲肾上腺素的产热效应的反应能力增加（VO 2：WAS的增加百分比，43 ± 0.0001）。5; WAC，88 .+-。6; CAS，75 .+-. [6] CAC，128 .+-. 5)肩胛间棕色脂肪组织（IBAT）（WAC，542 . ±. [27] CAS，469 .+-. [27] CAC，1111 .+-. 85 mg），与WAS对照组（339 . ±. 22mg）。当暴露于5.0 ℃时，C，WAS大鼠持续颤抖，而在WAC动物中颤抖5小时停止。WAC大鼠的直肠温度保持在比WAS组更高的水平（WAS，34.7 ± 0.01）。0.9.degree. C; WAC，36.2 .+-。0.5.degree. C; P < 0.01）。注射普萘洛尔降低了WAC大鼠的核心温度并导致颤抖重新开始，但对WAS大鼠没有影响。饮食和冷诱导的产热之间的相似性表明，两者都有一个共同的代谢来源，居住在BAT和饮食诱导的产热可能是重要的维持体温和能量平衡调节。
Rats were maintained at 24.degree. C (WA; warm-adapted) or 4.degree. C (CA; cold-adapted) and fed a pelleted stock diet (WAS, CAS) or a varied and palatable cafeteria diet (WAC, CAC). Resting O2 consumption (.ovrhdot.VO2, 29.degree. C) was significantly elevated by 15, 14 and 24% in WAC, CAS and CAC rats, respectively, compared with WAS controls. These differences were completely abolished by injection of propranolol in all but CAC rats, where .ovrhdot.VO2 remained slightly elevated. Experimental groups showed an increased capacity to respond to the thermogenic effects of norepinephrine (percentage increase in .ovrhdot.VO2: WAS, 43 .+-. 5; WAC, 88 .+-. 6; CAS, 75 .+-. 6; CAC, 128 .+-. 5) and greater deposits of interscapular brown adipose tissue (IBAT) (WAC, 542 .+-. 27; CAS, 469 .+-. 27; CAC, 1111 .+-. 85 mg), compared with WAS controls (339 .+-. 22 mg). When exposed to 5.degree. C, WAS rats shivered continuously, whereas in the WAC animals shivering had ceased by 5 h. Rectal temperature was maintained at a higher level in the WAC rats than in the WAS group (WAS, 34.7 .+-. 0.9.degree. C; WAC, 36.2 .+-. 0.5.degree. C; P < 0.01). Injection of propranolol lowered the core temperature of WAC rats and caused shivering to recommence, but had no effect on WAS rats. The similarities between diet- and cold-induced thermogenesis suggest that both have a common metabolic origin residing in BAT and that dietary-induced thermogenesis may be important in the maintenance of body temperature and in energy-balance regulation.