HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
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HIV 储存库大小在 ART 开始之前确定，并与 CD8 T 细胞激活和记忆扩展相关
DOI：
10.1101/580308
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Martin G
中科院分区：
文献类型：
--
作者：
Martin G
与慢性HIV感染相比，早期开始抗逆转录病毒治疗（ART）与较小的HIV储存库相关。对63名在原发性HIV感染（PHI）期间开始ART的个体进行的纵向分析调查了哪些治疗前和治疗后因素与PHI期间治疗开始后的水库大小（HIV DNA）最密切相关。一年时储库大小的最佳预测因子是ART前HIV DNA，其进而与CD 8记忆分化（效应记忆、幼稚和T-β Eomeslymphocyte亚群）、CD 8 T细胞活化（CD 38表达）以及记忆CD 4 T细胞上的PD-1和Tim-3表达显著相关。没有发现任何相关的免疫学变量后一年的ART。艾滋病毒水库的大小是确定在PHI期间治疗的个人ART开始的时间左右。CD 8 T细胞活化和记忆扩展与HIV储库大小有关，表明初始宿主-病毒相互作用在最终储库大小中的重要性。
Initiation of antiretroviral therapy (ART) in early compared with chronic HIV infection is associated with a smaller HIV reservoir. This longitudinal analysis of 63 individuals who commenced ART during primary HIV infection (PHI) investigates which pre-and post-therapy factors associate most closely with reservoir size (HIV DNA) following treatment initiation during PHI. The best predictor of reservoir size at one-year was pre-ART HIV DNA which was in turn significantly associated with CD8 memory differentiation (effector memory, naïve and T-betnegEomesnegsubsets), CD8 T cell activation (CD38 expression) and PD-1 and Tim-3 expression on memory CD4 T cells. No associations were found for any immunological variables following one-year of ART. HIV reservoir size is determined around the time of ART initiation in individuals treated during PHI. CD8 T cell activation and memory expansion are linked to HIV reservoir size, suggesting the importance of the initial host-viral interplay in eventual reservoir size.
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