In vitro analysis of age‐related changes in the developmental potential of bone marrow thymocyte progenitors
In vitro analysis of age‐related changes in the developmental potential of bone marrow thymocyte progenitors
复制标题
骨髓胸腺细胞祖细胞发育潜力与年龄相关变化的体外分析
DOI：
10.1002/eji.1830201203
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发表时间：
1990
影响因子：
5.4
通讯作者：
A. Globerson
中科院分区：
文献类型：
--
作者：
A. Sharp;Tova Kukulansky;A. Globerson
分析了来自骨髓（BM）的胸腺祖细胞发育能力与年龄相关的降低的潜在机制，重点关注这些细胞与胸腺微环境的相互作用。我们采用的实验模型中，年轻和老年小鼠骨髓细胞的混合物，同源的Thy-1标记，接种到胎儿胸腺（FT）外植体耗尽自身淋巴细胞和Thy-1+细胞的水平，从两种供体类型的发展进行了测量。当来自年轻和老年骨髓供体的细胞以饱和量同时接种时，从年轻供体产生更高水平的T细胞。
Mechanisms underlying the age‐related decrease in the developmental capacity of thymocyte progenitors from the bone marrow (BM) were analyzed, focussing on interactions of these cells with the thymic microenvironment. We employed the experimental model in which mixtures of young and old mouse BM cells, congenic for the Thy‐1 marker, were seeded onto fetal thymus (FT) explants depleted of self lymphocytes and the levels of Thy‐1+ cells developing from each of the two donor types were measured. When cells from young and old BM donors were seeded simultaneously, in saturating quantities, a higher level of T cells developed from the young donors.
可移植原始免疫造血干细胞的数量和功能。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Harrison,DE;Astle,CM;Stone,M
通讯作者：
Stone,M