Age and time-of-day differences in the hypothalamo-pituitary-testicular, and adrenal, response to total overnight sleep deprivation.
Age and time-of-day differences in the hypothalamo-pituitary-testicular, and adrenal, response to total overnight sleep deprivation.
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下丘脑-垂体-睾丸和肾上腺对整夜睡眠剥夺反应的年龄和时间差异。
DOI：
10.1093/sleep/zsaa008
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发表时间：
2020
期刊：
影响因子：
5.6
通讯作者：
Veldhuis,JohannesD
中科院分区：
文献类型：
--
作者：
Liu,PeterY;Takahashi,PaulY;Yang,RebeccaJ;Iranmanesh,Ali;Veldhuis,JohannesD
研究目的在年轻男性中，睡眠限制降低睾酮（Te），增加下午皮质醇（F），导致合成代谢-分解代谢失衡，胰岛素抵抗和其他男性健康后果。下丘脑-垂体-睾丸/肾上腺对睡眠限制的反应与睡眠相关的差异可能使老年人面临更大或更小的风险。我们的目的是评估和比较24小时和一天中的时间睡眠限制对F，促黄体生成激素（LH），和Te的影响，在年轻和老年男性Methods 35名健康男性，年龄18-30（n= 17）和60-80（n=18）岁，整夜被剥夺睡眠（完全夜间觉醒）或夜间睡眠（晚上10点至早上6点），同时进行10分钟采血。结果睡眠剥夺对24小时Te分泌有多重影响，在LH无明显变化的情况下，Te平均浓度、基础分泌、总分泌和脉动分泌以及脉冲频率均显著降低（eachp< 0.05）。这些影响在老年男性中最明显，并且根据年龄的不同，某些参数不同：脉冲式Te分泌（p= 0.03）和Te脉冲频率（p= 0.02）。时间的一天的分析显示，睡眠限制显着减少Te在上午和下午，减少LH在上午在两个年龄组，并增加F在下午在老年男子。ConclusionsThese data suggest a time-of-day dependent uncoupling of the regulatory control of the testicular axis and of F secretion.未来的研究将需要在年轻和老年男性中分别直接验证这些调节的可能性。
Study ObjectivesIn young men, sleep restriction decreases testosterone (Te) and increases afternoon cortisol (F), leading to anabolic–catabolic imbalance, insulin resistance, and other andrological health consequences. Age-related differences in the hypothalamo–pituitary–testicular/adrenal response to sleep restriction could expose older individuals to greater or lesser risk. We aimed to evaluate and compare the 24-h and time-of-day effect of sleep restriction on F, luteinizing hormone (LH), and Te in young and older men.MethodsThirty-five healthy men, aged 18–30 (n= 17) and 60–80 (n=18) years, underwent overnight sleep deprivation (complete nighttime wakefulness) or nighttime sleep (10 pm to 6 am) with concurrent 10-min blood sampling in a prospectively randomized crossover study. F, LH, and Te secretion were calculated by deconvolution analysis.ResultsSleep deprivation had multiple effects on 24-h Te secretion with significant reductions in mean concentrations, basal, total and pulsatile secretion, and pulse frequency (eachp< 0.05), in the absence of detectable changes in LH. These effects were most apparent in older men and differed according to age for some parameters: pulsatile Te secretion (p= 0.03) and Te pulse frequency (p= 0.02). Time-of-day analyses revealed that sleep restriction significantly reduced Te in the morning and afternoon, reduced LH in the morning in both age groups, and increased F in the afternoon in older men.ConclusionsThese data suggest a time-of-day dependent uncoupling of the regulatory control of the testicular axis and of F secretion. Future studies will need to directly verify these regulatory possibilities specifically and separately in young and older men.Clinical TrialNot applicable.