Highly enantioseletive biginelli reaction using a new chiral ytterbium catalyst: Asymmetric synthesis of dihydropyrimidines
Highly enantioseletive biginelli reaction using a new chiral ytterbium catalyst: Asymmetric synthesis of dihydropyrimidines
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DOI：
10.1021/ja056092f
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发表时间：
2005-11-30
影响因子：
15
通讯作者：
Zhu, CJ
中科院分区：
文献类型：
--
作者：
Huang, YJ;Yang, FY;Zhu, CJ
研究了一种可回收的手性三氟甲磺酸镱与一种新型的含吡啶基的六齿胺酚配体催化的高对映选择性的三组分Biginelli缩合反应。在温和的条件下，以高收率和良好的对映选择性获得了广泛的具有显着药理学意义的光学活性二氢嘧啶。
The highly enantioselective three-component Biginelli condensation catalyzed by a recyclable chiral ytterbium triflate with a novel hexadentate amine phenol ligand containing a pyridyl group has been developed. A wide range of optically active dihydropyrimidines with remarkable pharmacological interest was obtained in high yields with good to excellent enantioselectivities under mild conditions.