BEHAVIOR OF CELLS MUTANT FOR AN EGF RECEPTOR HOMOLOG OF DROSOPHILA IN GENETIC MOSAICS
BEHAVIOR OF CELLS MUTANT FOR AN EGF RECEPTOR HOMOLOG OF DROSOPHILA IN GENETIC MOSAICS
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DOI：
10.1098/rspb.1990.0100
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发表时间：
1990-10-22
影响因子：
4.7
通讯作者：
GARCIABELLIDO, A
中科院分区：
文献类型：
--
作者：
DIAZBENJUMEA, FJ;GARCIABELLIDO, A
表皮生长因子受体（DEGFr或DER，也称为torpedo或top）的果蝇同源物具有许多突变等位基因，可导致胚胎致死性（早期和晚期），蛹致死性或雌性不育，可能对应于半形性的程度。我们研究了一些致死等位基因在胸、头和蚁表皮想象发育过程中的克隆行为。这些等位基因导致不同程度的细胞活力降低（以克隆的频率和大小来衡量），细胞大小变小，感觉器官分化模式异常，以及大毛囊和静脉缺乏分化。这些影响是细胞自主的，但也会导致克隆周围野生型细胞的异常分化。此外，我们还研究了活顶等位基因与翼型突变体的双突变组合的表型，其中一些与果蝇的其他原癌基因有关，以揭示DER在细胞增殖和分化中的作用。我们讨论了这些复杂的细胞行为表型和遗传相互作用如何与DER的分子性质相关。
The Drosophila homologue of the epidermal growth factor receptor (DEGFr or DER, also called torpedo or top) has many mutant alleles that cause either embryonic lethality (both early and late), pupal lethality or female sterility, possibly corresponding to degrees of hypomorphism. We have studied the clonal behaviour of some lethal alleles in genetic mosaics in the imaginal development of thorax, head and tergite epidermis. These alleles cause reduced cell viability to different degrees (measured in frequency and size of clones), smaller cell sizes, abnormal patterning of sensory-organ differentiation and lack of differentiation of macro-chaetae and veins. These effects are cell-autonomous but also cause abnormal differentiation in wild-type cells surrounding the clones. In addition, we have studied the phenotypes of double mutant combinations of viable top alleles with wing-pattern mutants, some related to other Drosophila proto-oncogenes, to reveal gene interactions in the role(s) of DER in cell proliferation and differentiation. We discuss how those complex cell-behaviour phenotypes and genetic interactions are related to the molecular nature of the DER.