Ion Channels in the Heart.
Ion Channels in the Heart.
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DOI：
10.1002/cphy.c140069
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发表时间：
2015-07-01
影响因子：
5.8
通讯作者：
Ripplinger CM
中科院分区：
文献类型：
--
作者：
Bartos DC;Grandi E;Ripplinger CM
最佳的心脏功能取决于心脏各区域兴奋和收缩的适当时机，以及适当的心率。这是通过系统各组成部分的特殊电特性来实现的，包括窦房结、心房、房室结、his -浦肯野系统和心室。在这里，我们回顾了这些心脏区域的主要区域决定的电性质，并提出了关于区域心脏功能和功能障碍的分子和离子基础的可用数据。了解这些差异对心律失常机制和药物治疗的研究具有重要意义。
Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electrical properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His-Purkinje system, and ventricles. Here we review the major regionally-determined electrical properties of these cardiac regions and present the available data regarding the molecular and ionic bases of regional cardiac function and dysfunction. Understanding these differences is of fundamental importance for the investigation of arrhythmia mechanisms and pharmacotherapy.