The potential value of low-level serum interleukin-38 for the clinical diagnosis and risk prediction of hyperuricemia.
The potential value of low-level serum interleukin-38 for the clinical diagnosis and risk prediction of hyperuricemia.
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DOI：
10.1016/j.intimp.2022.109069
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发表时间：
2022-09
影响因子：
5.6
通讯作者：
Guoqing Huang;Qian-mei Jin;Mingcai Li;Xiao-ting Tian;Y. Mao;Yan Li
中科院分区：
文献类型：
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作者：
Guoqing Huang;Qian-mei Jin;Mingcai Li;Xiao-ting Tian;Y. Mao;Yan Li
白介素38(IL-38)是IL-1家族中一种新的抗炎细胞因子，在多种自身免疫性/炎症性疾病中发挥重要作用。高尿酸血症(HUA)患者血清IL-38水平及其临床意义尚不清楚。采用酶联免疫吸附试验检测受试者血清IL-38水平。采用多变量Logistic回归分析确定与HUA相关的独立危险因素。采用最小绝对收缩选择算子结合10次交叉验证筛选特征变量进行建模，并以诺模图的形式对Logistic回归模型进行可视化。结果华华患者血清IL-38水平较正常对照组降低(275.09±294.89 vs 505.99±312.94，P<；P<0.01)。以246.91 pg/ml为界值，血清IL-38曲线下面积为0.768。IL-38、血小板计数、平均血小板体积和总蛋白是HUA的独立危险因素。风险模型显示出良好的临床区分价值(曲线下面积：0.961)和拟合度。决策曲线分析表明，当阈值概率为1%~95%时，预测模型对患者是有利的。结论低水平血清IL-38在华华的临床诊断和风险预测中具有一定的潜力。此外，血清IL-38作为HUA的一种新的生物标志物，将为今后深入研究其发病机制奠定基础。
BackgroundInterleukin (IL)-38, a novel anti-inflammatory cytokine in the IL-1 family, has an important role in various autoimmune/inflammatory diseases. However, the level of serum IL-38 in hyperuricemia (HUA) and its clinical applications are still unknown.MethodsForty-four HUA patients and 43 healthy controls were enrolled in this study. The levels of serum IL-38 in the participants were detected by enzyme-linked immunosorbent assay. Multivariable logistic regression analysis was used to identify independent risk factors associated with HUA. The least absolute shrinkage and selection operator combined with 10-fold cross-validation was used to screen the characteristic variables for modeling and the logistic regression model was visualized by nomogram. The discrimination, degree of concordance, and clinical applicability of the models were evaluated by receiver operator characteristic curve, calibration plot, and decision curve analysis, respectively.ResultsCompared with that in healthy controls, the level of serum IL-38 was reduced in HUA patients (275.09 ± 294.89 vs 505.99 ± 312.94,P< 0.01). The area under the curve of serum IL-38 was 0.768 (cutoff value: 246.91 pg/ml). IL-38, platelet count, mean platelet volume, and total protein were identified as independent risk factors for HUA. The risk model showed an excellent clinical differentiation value (area under the curve: 0.961) and degree of fit. Decision curve analysis indicated that the prediction model could be beneficial for patients when the threshold probability was 1%–95%.ConclusionsLow level of serum IL-38 shows some potential in the clinical diagnosis and risk prediction of HUA. In addition, as a novel biomarker of HUA, serum IL-38 would contribute to the in-depth study of its pathogenesis in the future.