Balanced synaptic currents underlie low-frequency oscillations in the subiculum.
Balanced synaptic currents underlie low-frequency oscillations in the subiculum.
复制标题
平衡的突触电流是下托低频振荡的基础。
DOI：
10.1002/hipo.23131
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发表时间：
2019
期刊：
影响因子：
3.5
通讯作者：
White,JohnA
中科院分区：
文献类型：
--
作者：
Royzen,Feliks;Williams,Sylvain;Fernandez,FernandoR;White,JohnA
Numerous synaptic and intrinsic membrane mechanisms have been proposed for generating oscillatory activity in the hippocampus. Few studies, however, have directly measured synaptic conductances and membrane properties during oscillations. The time course and relative contribution of excitatory and inhibitory synaptic conductances, as well as the role of intrinsic membrane properties in amplifying synaptic inputs, remains unclear. To address this issue, we used an isolated whole hippocampal preparation that generates autonomous low‐frequency oscillations near the theta range. Using 2‐photon microscopy and expression of genetically encoded fluorophores, we obtained on‐cell and whole‐cell patch recordings of pyramidal cells and fast‐firing interneurons in the distal subiculum. Pyramidal cell and interneuron spiking shared similar phase‐locking to local field potential oscillations. In pyramidal cells, spiking resulted from a concomitant and balanced increase in excitatory and inhibitory synaptic currents. In contrast, interneuron spiking was driven almost exclusively by excitatory synaptic current. Thus, similar to tightly balanced networks underlying hippocampal gamma oscillations and ripples, balanced synaptic inputs in the whole hippocampal preparation drive highly phase‐locked spiking at the peak of slower network oscillations.
