Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies-Singletons Cohort.
Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies-Singletons Cohort.
复制标题
作者：
脂肪酸（FAs）与妊娠期糖尿病（GDM）的发生有关，但单不饱和脂肪酸（MUFAs）的作用仍有待研究。我们研究了妊娠早期至中期血浆磷脂MUFAs与心脏代谢生物标志物和GDM风险的关系。从Eunice Kennedy Shriver国家儿童健康和人类发育研究所（NICHD）的胎儿生长发育-单胎队列（2009-2013）中，我们根据Carpenter和Coustan标准确定了107名GDM女性，并在年龄，种族/民族和采血孕周（GW）方面匹配（2：1）214名对照参与者。通过气相色谱质谱法在10-14、15-26、23-31和33-39 GW处测量MUFA。我们发现，在15-26 GWs时，GDM妇女的总18：1 MUFA浓度显著低于非GDM妇女。在15-26 GW时，在总18：1 MUFA水平上的每个SD增量与GDM风险降低40%相关。此外，在10-14和15-26 GW时，异油酸（18：1 n-7）水平的每个SD增量分别与GDM风险降低36%和45%相关。我们对MUFAs的广泛评估促进了我们对FA成分与GDM风险的独特关联的理解，表明MUFAs在GDM病理生理学中的潜在有益作用。
Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009–2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10–14, 15–26, 23–31, and 33–39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15–26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15–26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10–14 and 15–26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.