Prolonged antagonism of morphine-induced locomotor stimulation by kappa opioid agonists: enhancement by prior morphine exposure.
Prolonged antagonism of morphine-induced locomotor stimulation by kappa opioid agonists: enhancement by prior morphine exposure.
复制标题
卡帕阿片受体激动剂对吗啡诱导的运动刺激的长期拮抗作用：通过先前的吗啡暴露而增强。
DOI：
10.1016/0304-3940(96)12822-6
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发表时间：
1996
影响因子：
2.5
通讯作者：
Glick,SD
中科院分区：
文献类型：
--
作者：
Pearl,SM;Glick,SD
选择性κ激动剂U 50488（10 mg/kg，i. p.）和螺吲哚啉（lmg/kg，i. p.）减弱吗啡攻击（5 mg/kg，i. p.）19小时后在大鼠中施用。κ激动剂对吗啡的这种拮抗作用可被选择性κ拮抗剂norbinaltorphimine（10 mg/kg，s.c.）逆转。此外，吗啡的κ阿片拮抗作用通过先前的吗啡暴露（2次剂量30 mg/kg，i. p.给药，每天一次，持续2天）增强。目前的数据表明，κ-μ阿片相互作用可能发生在超过药物作用急性持续时间的时间段内。
The selective κ agonists U50488 (10 mg/kg, i.p.) and spiradoline (1 mg/kg, i.p.) attenuated the locomotor activating effects of a morphine challenge (5 mg/kg, i.p.) administered 19 h later in rats. This antagonism of morphine by a κ agonist was reversed by the selective κ antagonist, norbinaltorphimine (10 mg/kg, s.c.). Furthermore, the κ opioid antagonism of morphine was enhanced by prior morphine exposure (2 doses of 30 mg/kg, i.p. administered once a day for 2 days). The present data suggest that κ-μ opioid interactions may occur over time periods that exceed the acute durations of drug actions.