Mouse models for cancer stem cell research.
Mouse models for cancer stem cell research.
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DOI：
10.1177/0192623309354109
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发表时间：
2010-01
影响因子：
1.5
通讯作者：
Nikitin AY
中科院分区：
文献类型：
--
作者：
Cheng L;Ramesh AV;Flesken-Nikitin A;Choi J;Nikitin AY
癌症干细胞的概念假设癌症主要是由一小群肿瘤细胞维持的，这些肿瘤细胞被称为癌症干细胞或肿瘤起始细胞，它们能够自我复制并产生具有较小致瘤潜力的表型异质性细胞。癌症干细胞代表了开发更具选择性和有效治疗的有吸引力的靶点。然而，直接测试癌症干细胞的概念和评估其在人类癌症中的治疗意义，由于使用免疫功能低下的小鼠而变得复杂。遗传定义的免疫活性人类癌症的本地小鼠模型提供了一个有价值的工具来解决这个问题。此外，它们允许更好地理解控制正常干细胞隔室与致癌作用的机制的相关性。一些现有的小鼠模型的优点和缺点将进行审查，并在癌症干细胞研究的未来挑战将概述。
Cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appealing target for development of more selective and efficient therapies. However, direct testing of the cancer stem cell concept and assessment of its therapeutic implications in human cancers has been complicated by the use of immunocompromised mice. Genetically defined immunocompetent autochthonous mouse models of human cancer provide a valuable tool to address this problem. Furthermore, they allow for a better understanding of the relevance of mechanisms controlling normal stem cell compartment to carcinogenesis. Advantages and disadvantages of some of the existing mouse models will be reviewed and future challenges in cancer stem cell research will be outlined.
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影响因子：
82.9
作者：
Dinulescu, DM;Ince, TA;Jacks, T
通讯作者：
Jacks, T
影响因子：
11.2
作者：
Collins, AT;Berry, PA;Maitland, NJ
通讯作者：
Maitland, NJ
影响因子：
5.2
作者：
Cho, Robert W.;Wang, Xinhao;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
64.5
作者：
Fuchs E
通讯作者：
Fuchs E
DOI：
10.4161/cc.8.1.7533
发表时间：
2009-01-01
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Alvero AB;Chen R;Fu HH;Montagna M;Schwartz PE;Rutherford T;Silasi DA;Steffensen KD;Waldstrom M;Visintin I;Mor G
通讯作者：
Mor G