Treatment of human pulmonary paragonimiasis with triclabendazole:: clinical tolerance and drug efficacy
Treatment of human pulmonary paragonimiasis with triclabendazole:: clinical tolerance and drug efficacy
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DOI：
10.1016/s0035-9203(98)90919-1
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发表时间：
1998-09-01
影响因子：
2.2
通讯作者：
Cooper, PJ
中科院分区：
文献类型：
--
作者：
Calvopiña, M;Guderian, RH;Cooper, PJ
对厄瓜多尔亚马逊地区62例肺吸虫病患者进行了一项开放的临床试验，以确定餐后剂量三氯苯达唑对墨西哥并殖吸虫的疗效和耐受性。以吡喹酮为治疗对照。随机分为4组：三氯苯咪唑5 mg/kg，每日1次，共3d；10 mg/kg，每日2次，共3d；吡喹酮，每日3次，每次25 mg/kg，共3d。根据不良反应的频率和严重程度，三种三氯苯达唑方案的临床耐受性均优于吡喹酮。未观察到肝肾功能或血液学指标的改变。临床症状在所有4个治疗组中的消退率相同。用三氯苯达唑治疗的患者比用吡喹酮治疗的患者对治疗的寄生虫学反应更快，这取决于在痰中发现的平均寄生虫卵数量的减少。到第90天，60例患者的痰中未检出虫卵；2例患者单次注射IO mg/kg后出现少量虫卵，并再次使用三氯苯咪唑(5 mg/d，连续3d)治疗。在第365天，没有一名患者的痰中有虫卵。三氯苯达唑可被推荐作为治疗肺吸虫病的替代药物；它在清除感染方面与吡喹酮一样有效，且耐受性更好。
An open clinical trial to determine the efficacy and tolerability of postprandial doses of triclabendazole against Paragonimus mexicanus in 62 patients with pulmonary paragonimiasis from the Ecuadorian Amazon region was performed. Praziquantel was used as therapeutic control. Patients were allocated at random to the following 4 therapeutic regimens: triclabendazole, 5 mg/kg once daily for 3 d (16 patients), 10 mg/kg twice on one day (15 patients), and 10 mg/kg in a single dose (16 patients), and praziquantel, 25 mg/kg thrice daily for 3 d (15 patients). Clinical tolerance, based on the frequency and severity of adverse reactions, was superior in all 3 triclabendazole regimens to that of praziquantel. No alteration was observed in hepato-renal functions or haematological values. The clinical symptoms resolved at a comparable rate in all 4 treatment groups. A more rapid parasitological response to treatment, as determined by the reduction in the average number of parasite eggs found in sputum, was seen in patients treated with triclabendazole than with praziquantel. By day 90, 60 patients had no egg detected in their sputum; 2 patients, treated with a single dose of IO mg/kg, had a few and were re-treated with triclabendazole (5 mg daily for 3 d). On day 365, none of the patients had eggs in their sputum. Triclabendazole can be recommended as an alternative drug of choice for the treatment of pulmonary paragonimiasis; it is as effective as praziquantel in clearing infections and better tolerated.