REGULATION OF PROTEIN-SYNTHESIS BY MESSENGER-RNA STRUCTURE
REGULATION OF PROTEIN-SYNTHESIS BY MESSENGER-RNA STRUCTURE
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DOI：
10.1007/bf00986961
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发表时间：
1994-05-01
影响因子：
2.8
通讯作者：
HENTZE, MW
中科院分区：
文献类型：
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作者：
GRAY, NK;HENTZE, MW
除了 m(7)G 帽结构、5' UTR 的长度以及 AUG 起始密码子的位置和上下文（已在本卷其他地方讨论过）之外，mRNA 内的高级结构代表了翻译的关键参数。将主要考虑 RNA 结构在翻译起始中的作用，尽管也发现结构元件影响翻译延伸和终止。我们将首先描述高级RNA结构本身的不同作用，然后考虑通过为调节蛋白提供结合位点来控制翻译起始的RNA结构元件的具体例子。
In addition to the m(7)G cap structure, the length of the 5' UTR and the position and context of the AUG initiator codon (which have been discussed elsewhere in this volume), higher order structures within mRNA represent a critical parameter for translation, The role of RNA structure in translation initiation will be considered primarily, although structural elements have also been found to affect translation elongation and termination. We will first describe the different effects of higher order RNA structures per se, and then consider specific examples of RNA structural elements which control translation initiation by providing binding sites for regulatory proteins.