Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats
Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats
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DOI：
10.3945/jn.111.137877
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Brown, Lindsay
中科院分区：
文献类型：
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作者：
Panchal, Sunil K.;Poudyal, Hemant;Brown, Lindsay
代谢综合征（肥胖、糖尿病和高血压）会增加肝脏和心血管损伤。本研究研究了高碳水化合物、高脂肪饮食喂养的大鼠对芦丁的预防或逆转反应，作为代谢综合征的模型。将大鼠分为6组：2组饲喂富含玉米淀粉的饮食8或16周，2组饲喂高碳水化合物、高脂肪的饮食8或16周，2组在16周方案的最后8周仅饲喂两种饮食中的芦丁（1.6 g/kg）。然后评估这些大鼠的代谢变化以及肝脏和心血管结构和功能。富含玉米淀粉的饮食中含有68%的碳水化合物（主要是玉米淀粉）和0.7%的脂肪，而高碳水化合物、高脂肪饮食中含有50%的碳水化合物（主要是果糖）和24%的脂肪（主要是牛油），饮用水中含有25%的果糖（按平均食物和水摄入量计算，总碳水化合物含量为68%）。高碳水化合物、高脂肪饮食导致肥胖、血脂异常、高血压、糖耐量受损、肝脂肪变性、肝脏和心脏炎症细胞浸润、心脏僵硬度升高、内皮功能障碍、血浆氧化应激标志物升高、肝脏氧化应激和细胞凋亡标志物表达降低。芦丁逆转或阻止代谢变化，如腹部脂肪垫和葡萄糖耐量，逆转或阻止肝脏和心血管结构和功能的变化，逆转肝脏和心脏的氧化应激和炎症，并使肝脏标志物的表达正常化。这些结果表明，芦丁的非营养作用，以减轻代谢综合征的慢性变化。中国生物医学工程学报，21(3):369 - 369,2011。
Metabolic syndrome (obesity, diabetes, and hypertension) increases hepatic and cardiovascular damage. This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome. Rats were divided into 6 groups: 2 groups were fed a corn starch-rich diet for 8 or 16 wk, 2 groups were fed a high-carbohydrate, high-fat diet for 8 or 16 wk, and 2 groups received rutin (1.6 g/kg diet) in either diet for the last 8 wk only of the 16-wk protocol. Metabolic changes and hepatic and cardiovascular structure and function were then evaluated in these rats. The corn starch-rich diet contained 68% carbohydrate (mainly cornstarch) and 0.7% fat, whereas the high-carbohydrate, high-fat diet contained 50% carbohydrate (mainly fructose) and 24% fat (mainly beef tallow) along with 25% fructose in drinking water (total 68% carbohydrate using mean food and water intakes). The high-carbohydrate, high-fat diet produced obesity, dyslipidemia, hypertension, impaired glucose tolerance, hepatic steatosis, infiltration of inflammatory cells in the liver and the heart, higher cardiac stiffness, endothelial dysfunction, and higher plasma markers of oxidative stress with lower expression of markers for oxidative stress and apoptosis in the liver. Rutin reversed or prevented metabolic changes such as abdominal fat pads and glucose tolerance, reversed or prevented changes in hepatic and cardiovascular structure and function, reversed oxidative stress and inflammation in the liver and heart, and normalized expression of liver markers. These results suggest a non-nutritive role for rutin to attenuate chronic changes in metabolic syndrome. J. Nutr. 141: 1062-1069, 2011.