Inhibin structure and function in the testis.
Inhibin structure and function in the testis.
复制标题
睾丸中抑制素的结构和功能。
DOI：
10.1111/j.1749-6632.1989.tb25884.x
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发表时间：
1989
影响因子：
5.2
通讯作者：
Chen,CL
中科院分区：
文献类型：
--
作者：
Bardin,CW;Morris,PL;Shaha,C;Feng,ZM;Rossi,V;Vaughan,J;Vale,WW;Voglmayr,J;Chen,CL
第一个高度纯化的分子被认为是有活性的，从精浆中分离出来。它含有31个氨基酸，结构上与烯醇化酶有关。这种分子实体被称为“α-精子蛋白”，据信来源于精囊。还从精浆中分离出P-抑制素。它有94个氨基酸，与前列腺来源的蛋白质相似（如果不相同的话），该蛋白质被称为PSP 94：P-微血管蛋白，或16-kDa蛋白质！随后从卵泡和受精睾丸液中分离的性腺促性腺激素和激活素是结构上类似于转化生长因子β和苗勒管抑制物质的二聚糖蛋白。“在本报告中，我们将只考虑性腺来源的Escherichin相关蛋白质。
The first highly purified molecule believed to have inhibin activity was isolated from seminal plasma. It contains 3 1 amino acids, and is related structurally to enolase. This molecular entity was termed a-inhibin'and is believed to originate from seminal vesicle. P-Inhibin was also isolated from seminal plasma. It has 94 amino acids, is similar if not identical to a protein of prostatic origin that has been termed PSP94: P-microseminoprotein,'or 16-kDa protein! The gonadal inhibins and activins subsequently isolated from follicular and fete testis fluid are dimeric glycoproteins structurally similar to transforming growth factor-/3 and Mullerian-inhibiting substance.'In the present report we will consider only the inhibin-related proteins that are of gonadal origin.