Redox Control of the Dormant Cancer Cell Life Cycle.
Redox Control of the Dormant Cancer Cell Life Cycle.
复制标题
休眠癌细胞生命周期的氧化还原控制。
DOI：
10.3390/cells10102707
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发表时间：
2021-10-09
期刊：
影响因子：
6
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Li B;Huang Y;Ming H;Nice EC;Xuan R;Huang C
Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances indicate that redox mechanisms control the dormant cancer cell life cycle, including dormancy entrance, long-term dormancy, and metastatic relapse. This regulatory network is orchestrated mainly through redox modification on key regulators or global change of reactive oxygen species (ROS) levels in dormant cancer cells. Encouragingly, several strategies targeting redox signaling, including sleeping, awaking, or killing dormant cancer cells are currently under early clinical evaluation. However, the molecular mechanisms underlying redox control of the dormant cancer cell cycle are poorly understood and need further exploration. In this review, we discuss the underlying molecular basis of redox signaling in the cell life cycle of dormant cancer and the potential redox-based targeting strategies for eliminating dormant cancer cells.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
5.6
作者：
Abuna, Robrigo P. F.;De Oliveira, Fabiola S.;Beloti, Marcio M.
通讯作者：
Beloti, Marcio M.
影响因子：
5
作者：
Decker, Ann M.;Decker, Joseph T.;Taichman, Russell S.
通讯作者：
Taichman, Russell S.
DOI：
10.1038/s41568-020-00312-2
发表时间：
2021-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Chen X;Cubillos-Ruiz JR
通讯作者：
Cubillos-Ruiz JR
影响因子：
3.6
作者：
Chen, Tao;Ren, Zhong;Zhong, Yun-Shi
通讯作者：
Zhong, Yun-Shi