B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer.
B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer.
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B淋巴瘤Moloney鼠白血病病毒插入区域1：前列腺癌中的致癌介质。
DOI：
10.4103/aja.aja_38_18
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发表时间：
2019-05
影响因子：
2.9
通讯作者：
Cao Q
中科院分区：
文献类型：
--
作者：
Liu Q;Li Q;Zhu S;Yi Y;Cao Q
B淋巴瘤Moloney小鼠白血病病毒插入区1 （BMI1）是多梳抑制复合体1 （PRC1）的核心成员，几十年来在癌症表观遗传学领域得到了广泛的研究。BMI1被广泛认为是细胞生理学的关键调节因子，在不同谱系的干细胞的自我更新和分化中是必不可少的。BMI1还在癌症病因学中发挥重要作用，参与病理过程，如上皮-间质转化（EMT）和癌症干细胞的维持、繁殖和分化。重要的是，BMI1的过表达可预测各种癌症亚型的耐药、肿瘤复发和最终治疗失败，这使得以BMI1为靶点的药理学治疗成为一种新颖而有前景的治疗方法。前列腺癌是男性中常见的一种激素相关癌症，对前列腺癌的研究促进了癌症遗传学和表观遗传学的巨大研究进展。本文综述了BMI1在前列腺癌肿瘤发生、进展和复发中的作用。
B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial–mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation. Importantly, overexpression of BMI1 is predictive for drug resistance, tumor recurrence, and eventual therapy failure of various cancer subtypes, which renders the pharmacological targeting at BMI1 as a novel and promising therapeutic approach. The study on prostate cancer, a prevalent hormone-related cancer among men, has promoted enormous research advancements in cancer genetics and epigenetics. This review summarizes the role of BMI1 as an oncogenic and epigenetic regulator in tumor initiation, progression, and relapse of prostate cancer.
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影响因子：
28.5
作者：
Bolomsky A;Schlangen K;Schreiner W;Zojer N;Ludwig H
通讯作者：
Ludwig H
DOI：
10.1038/nrurol.2011.208
发表时间：
2011-12-27
期刊：
Nature reviews. Urology
影响因子：
--
作者：
Clyne, Melanie
通讯作者：
Clyne, Melanie
DOI：
10.1056/nejmoa1315815
发表时间：
2014-09-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Antonarakis ES;Lu C;Wang H;Luber B;Nakazawa M;Roeser JC;Chen Y;Mohammad TA;Chen Y;Fedor HL;Lotan TL;Zheng Q;De Marzo AM;Isaacs JT;Isaacs WB;Nadal R;Paller CJ;Denmeade SR;Carducci MA;Eisenberger MA;Luo J
通讯作者：
Luo J
DOI：
10.1038/nrm4067
发表时间：
2015-11
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Blackledge NP;Rose NR;Klose RJ
通讯作者：
Klose RJ
影响因子：
4.8
作者：
Cho, Joon-Ho;Dimri, Manjari;Dimri, Goberdhan P.
通讯作者：
Dimri, Goberdhan P.