UHRF1: a novel metabolic guardian restricting AMPK activity.
UHRF1: a novel metabolic guardian restricting AMPK activity.
复制标题
UHRF1：一种限制 AMPK 活性的新型代谢卫士。
DOI：
10.1038/s41422-021-00589-4
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发表时间：
2022
期刊：
影响因子：
44.1
通讯作者：
Lin,Hui-Kuan
中科院分区：
文献类型：
--
作者：
Hsu,Che-Chia;Tsai,Yau-Sheng;Lin,Hui-Kuan
AMP激活蛋白激酶（AMPK）是营养胁迫和/或能量危机时维持能量稳态的中枢卫士。Xu等人的研究发现，核因子UHRF 1（具有植物同源结构域和RING指结构域的泛素样结构域1）通过募集PP 2A在T172使AMPK去磷酸化来抑制细胞核中的AMPK活性，其反过来控制细胞质AMPK活性以调节葡萄糖和脂质代谢。真核细胞通过激活AMP来操作内在机制以感知能量的不平衡，活化蛋白激酶（AMPK），其作为监护者调节响应于各种环境损伤的多种信号和代谢途径。AMPK作为一种能量传感器，通过磷酸化参与细胞代谢重编程的几种关键代谢蛋白来维持能量稳态和细胞存活。1. AMPK在不同的应激反应中激活，触发分解代谢，但关闭合成代谢。1全面了解AMPK激活在能量应激下的调节机制，对于代谢性疾病和癌症的治疗提供见解和策略至关重要。1
AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis under nutrient stress and/or energy crisis. The study by Xu et al. identified that a nuclear factor UHRF1 (ubiquitin-like with plant homeodomain and RING finger domains 1) suppresses AMPK activity in the nucleus by recruiting PP2A to dephosphorylate AMPK at T172, which in turn governs cytoplasmic AMPK activity in regulation of glucose and lipid metabolism.Eukaryotic cells operate the intrinsic mechanism to sense the imbalance of energy through activation of AMP-activated protein kinase (AMPK), which serves as a guardian to regulate diverse signal and metabolic pathways in response to various environmental insults. AMPK serves as an energy sensor to maintain energy homeostasis and cell survival by phosphorylating several key metabolic proteins involved in reprograming the cellular metabolism. 1 AMPK activation in response to distinct stresses triggers catabolic metabolism, but turns off anabolic metabolism. 1 To comprehensively understand the mechanism of how AMPK activation is modulated upon energy stress is pivotal for offering the insight and strategy into the treatment for metabolic diseases and cancer. 1