Stem cells in genetically-engineered mouse models of prostate cancer.
Stem cells in genetically-engineered mouse models of prostate cancer.
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DOI：
10.1530/erc-15-0367
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发表时间：
2015-12
影响因子：
3.9
通讯作者：
Shen MM
中科院分区：
文献类型：
--
作者：
Shibata M;Shen MM
癌症干细胞模型提出，肿瘤具有分层组织，其中致瘤细胞产生非致瘤细胞，只有一部分干细胞样细胞能够繁殖肿瘤。在前列腺癌的情况下，最近对基因工程小鼠（GEM）模型的分析提供了支持体内癌症干细胞存在的证据。这些研究表明，能够肿瘤增殖的癌症干细胞存在于从前列腺上皮内瘤变（PIN）到晚期转移性和去势抵抗性疾病的肿瘤进展的各个阶段。然而，前列腺癌干细胞的研究受到现有方法的限制，用于评估其在细胞培养和移植试验中的功能特性。考虑到肿瘤微环境和假定的癌症干细胞生态位的作用，未来使用GEM模型分析癌症干细胞在其天然组织微环境中的研究可能具有高度的信息性。
The cancer stem cell model proposes that tumors have a hierarchical organization in which tumorigenic cells give rise to non-tumorigenic cells, with only a subset of stem-like cells able to propagate the tumor. In the case of prostate cancer, recent analyses of genetically engineered mouse (GEM) models have provided evidence supporting the existence of cancer stem cells in vivo. These studies suggest that cancer stem cells capable of tumor propagation exist at various stages of tumor progression from prostatic intraepithelial neoplasia (PIN) to advanced metastatic and castration-resistant disease. However, studies of stem cells in prostate cancer have been limited by available approaches for evaluating their functional properties in cell culture and transplantation assays. Given the role of the tumor microenvironment and the putative cancer stem cell niche, future studies using GEM models to analyze cancer stem cells in their native tissue microenvironment are likely to be highly informative.