Lipoprotein Lp(a): A Risk Factor for Myocardial Infarction
Lipoprotein Lp(a): A Risk Factor for Myocardial Infarction
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脂蛋白 Lp(a)：心肌梗塞的危险因素
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
G. Kostner
中科院分区：
文献类型：
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作者：
G. Hoefler;F. Harnoncourt;E. Paschke;Wolfgang Mirti;K. Pfeiffer;G. Kostner
本研究的目的是检测血浆脂蛋白Lp(a)和其他lipkj和脂蛋白水平与心肌梗死发生率的关系。对1486名18岁男性进行了血浆总胆固醇、三甘油酯、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和脂蛋白(a)的测定。此外，还记录了Broca指数（一种相对体重的衡量指标）和其他数据。将样本分为母亲或父亲患有心肌梗死的先证者（病例组，n=52）和父母无心肌梗死的先证者（对照组，n= 1434）。在病例组中，32%的患者血浆中Lp(a)浓度大于25 mg/dl，而对照组中只有13.4%的患者血浆中Lp(a)浓度大于25 mg/dl，差异极显著（p<0.01）。低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值（p<0.05）、Broca指数（p<0.01）与对照组比较差异均有统计学意义。病例组家长年龄明显大于对照组家长；然而，当对照组与父母的年龄相匹配时，结果是相似的。这些数据表明，血浆Lp(a)浓度大于25 mg/dl的男性儿童的父母心肌梗死发生率高出2.5倍。考虑到Lp(a)水平升高的家族聚集性，我们得出结论，这种脂蛋白水平升高可能是心肌梗死的一个重要危险因素。
The aim of this study was to test plasma lipoprotein Lp(a) and other lipkj and lipoprotein levels for association with the Incidence of myocardial Infarction. Total plasma cholesterol, trlglycerides, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and Lp(a) were measured In 1486 men at the age of 18 years. In addition, the Broca Index (a measure of relative body weight) and other data were recorded. The sample was divided Into probands whose mothers or fathers suffered a myocardial Infarction (case group, n=52) and Into probands whose parents had no myocardial Infarction (control group, n = 1434). In the case group, 32% had Lp(a) plasma concentrations greater than 25 mg/dl, but only 13.4% of the control group had this level of concentration, a highly significant difference (p<0.01). In addition, there was a statistically significant difference In the ratio of LDL cholesterol/HDL cholesterol (p<0.05) and the Broca Index (p<0.01) between cases and controls. The parents of the case group were significantly older than the parents of the control group; however, when a control group was matched for parents' age, the result* were similar. These data suggest that parents of male children with Lp(a) plasma concentrations greater than 25 mg/dl have a 2.5-fold higher Incidence of myocardial Infarction. Considering the familial aggregation of elevated Lp(a) levels, we conclude that increased levels of this lipoprotein may be a significant risk factor for myocardial infarction.