Kinetics of degradation of cinnarizine in aqueous solution.
Kinetics of degradation of cinnarizine in aqueous solution.
复制标题
桂利嗪在水溶液中的降解动力学。
DOI：
10.1248/cpb.33.2069
复制
发表时间：
1985
影响因子：
1.7
通讯作者：
T. Nagai
中科院分区：
文献类型：
--
作者：
T. Tokumura;T. Ichikawa;N. Sugawara;K. Tatsuishi;M. Kayano;Y. Machida;H. Hoshida;T. Nagai
研究了桂利嗪在不同pH值和不同温度下的降解动力学。桂利嗪的降解符合准一级反应。通过测定桂利嗪在不同pH值下的降解率，发现在pH 3.0 ~ 1.0范围内，桂利嗪的降解率随pH的降低而增加。在低于pH 1.2时速率保持不变，桂利嗪在高于pH 3.0时稳定。在60、70、80和90°C时，水溶液（pH 1.20）中的假一级反应速率常数分别为1.85×10-5、1.05×10-4、4.07×10-4和1.94×10-3 min-1。在水溶液（pH 1.20）中的降解的活化能计算为36.8 kcal/mol从Arrhenius图。
The kinetics of the degradation of cinnarizine in aqueous solution at various pH values and four different temperatures were investigated. The degradation of cinnarizine was observed as a pseudo first-order reaction. By determining the degradation rate of cinnarizine at various pH values, it was found that the degradation rate of cinnarizine increased with decreasing pH within the range from pH 3.0 to 1.0. The rate remained unchanged at below pH 1.2, and cinnarizine was stable at above pH 3.0. The pseudo first-order rate constants in aqueous solution (pH 1.20) at 60, 70, 80 and 90°C were 1.85×10-5, 1.05×10-4, 4.07×10-4 and 1.94×10-3 min-1, respectively. The activation energy of degradation in aqueous solution (pH 1.20) was calculated to be 36.8 kcal/mol from an Arrhenius plot.