Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review
Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review
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DOI：
10.1080/09553000310001642920
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Moulder, JE
中科院分区：
文献类型：
--
作者：
Moulder, JE
目的：最近发生的事件引起了人们对放射性（核）恐怖主义的可能性以及此类恐怖主义威胁对辐射事故防备的影响的关注。这篇综述讨论了如何用药物治疗此类事件造成的辐射损伤的最新进展，以及这些方法临床应用的实际障碍。结论：实验室正在开发多种药理学方法，可以极大地扩展治疗急性和慢性辐射损伤的能力。然而，目前存在各种实际和法律障碍，阻碍了大多数方法的实际临床使用。目前处理辐射事故或核恐怖主义后果的大多数计划也存在潜在的弱点，包括缺乏广泛的辐射生物剂量测定能力以及由此导致的无法分类。如果发生重大辐射事故或恐怖事件，生物剂量测定和治疗能力的缺乏将因公众对“辐射”的普遍恐惧而变得更加严重。
Purpose: Events of the recent past have focused attention on the possibility of radiological (nuclear) terrorism and on the implications of such terrorist threats for radiation accident preparedness. This review discusses recent advances in the knowledge about how radiation injuries from such events might be treated pharmacologically, and the practical barriers to clinical utilization of these approaches.Conclusions: A wide range of pharmacological approaches are being developed in the laboratory that could greatly expand the ability to treat acute and chronic radiation injuries. However, there are currently a variety of practical and legal barriers that would prevent the actual clinical use of most of the approaches. There are also the potential weaknesses in most of the current programmes for dealing with the consequences of radiation accidents or nuclear terrorism, including the absence of widespread radiation biodosimetry capabilities and the resulting inability to triage. If a major radiation accident or terrorist event occurs, the lack of biodosimetry and treatment capabilities will be compounded by widespread public fear of 'radiation'.