Cohort Profile: A population-based cohort to study non-motor symptoms in parkinsonism (EPIPARK)
Cohort Profile: A population-based cohort to study non-motor symptoms in parkinsonism (EPIPARK)
复制标题
DOI：
10.1093/ije/dys202
复制
发表时间：
2013-02-01
影响因子：
7.7
通讯作者：
Klein, Christine
中科院分区：
文献类型：
--
作者：
Kasten, Meike;Hagenah, Johann;Klein, Christine
帕金森病越来越被视为一种复杂的疾病，除了主要的运动体征外，还包括一系列典型的非运动症状。该队列成立于2010年，旨在研究帕金森病非运动症状的特异性。为此，我们纳入了几个对照组，帕金森病患者的对比度降低。组定义范围从健康对照受试者到疑似帕金森综合征早期运动体征的受试者。使用邮寄的问卷，我们筛选了5838吕贝克，德国，从10 000名公民的目标人群，询问有关运动障碍，疼痛，生活质量，合并症，躯体化和人口统计学。根据这些信息，将参与者分配到筛选组，并邀请选定的参与者进行面对面检查（n = 623）。检查包括认知检查、经颅超声、简短的精神病学访谈和用于分配检查组的标准化运动检查。此外，所有参与者都回答了关于抑郁、焦虑、睡眠和生活质量的问卷。第一年的随访检查是亲自使用相同的协议或通过邮寄问卷进行。本研究正在进行中，出版物正在准备中，但您可以联系第一作者（meike.卡斯滕），提出合作建议或数据请求。neuro.uni-luebeck.de
Parkinson's disease is increasingly viewed as a complex disorder including a range of typical non-motor symptoms in addition to the cardinal motor signs. This cohort was set up in 2010 to investigate the specificity of non-motor symptoms for Parkinson's disease. For this, we included several control groups with decreasing contrast from Parkinson's disease patients. Group definitions ranged from healthy control subjects to those with suspected early motor signs of parkinsonism. Using a mailed questionnaire, we screened 5838 inhabitants of Lubeck, Germany, out of a target population of 10 000 citizens, enquiring about motor impairment, pain, quality of life, comorbidities, somatization and demographics. Based on this information, participants were assigned to screening groups, and selected participants were invited for in-person examination (n = 623). The examination included cognitive examinations, transcranial ultrasound, a brief psychiatric interview and a standardized motor examination that was used to assign examination groups. In addition, all participants answered questionnaires addressing depression, anxiety, sleep and quality of life. The first-year follow-up examination was performed either in person using the same protocol or via mailed questionnaires. This study is ongoing and publications are in preparation, but you may contact the first author (meike.kasten@neuro.uni-luebeck.de) with suggestions for collaboration or data requests.